This HTML5 document contains 49 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n6http://linked.opendata.cz/resource/domain/vavai/projekt/
n5http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n14http://linked.opendata.cz/resource/domain/vavai/subjekt/
n13http://linked.opendata.cz/ontology/domain/vavai/
n17http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00209805%3A_____%2F12%3A%230000458%21RIV14-GA0-00209805/
shttp://schema.org/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
rdfshttp://www.w3.org/2000/01/rdf-schema#
skoshttp://www.w3.org/2004/02/skos/core#
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n9http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n19http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n10http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n15http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F12%3A%230000458%21RIV14-GA0-00209805
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://www.linkos.cz/files/klinicka-onkologie/174/4115.pdf
dcterms:description
p63 is a transcription factor which plays an important role in epidermal development, differentiation and tumourigenesis. p63 belongs to the p53 protein family and at least six isoforms were identified to date. p63 isoforms play contrary roles during the development and formation of the epidermis as well as in cancer. p63 participates in epithelial development, where it affects proliferation and differentiation of epidermal cells. Inherited mutations in the TP63 gene generate different developmental defects and p63 knockout in mice results in the absence of epidermis. Another important role of p63 is the control of cell-cell adhesion, where it regulates desmosomes. The loss of proliferation and cell-cell adhesion control are important for tumourigenesis and overexpression of p63 can enhance tumour growth and inhibit apoptosis. This review briefly summarises the roles of p63 in epithelial development, cellular proliferation, adhesion and migration and reveals its share in tumourigenesis and metastasis. p63 is a transcription factor which plays an important role in epidermal development, differentiation and tumourigenesis. p63 belongs to the p53 protein family and at least six isoforms were identified to date. p63 isoforms play contrary roles during the development and formation of the epidermis as well as in cancer. p63 participates in epithelial development, where it affects proliferation and differentiation of epidermal cells. Inherited mutations in the TP63 gene generate different developmental defects and p63 knockout in mice results in the absence of epidermis. Another important role of p63 is the control of cell-cell adhesion, where it regulates desmosomes. The loss of proliferation and cell-cell adhesion control are important for tumourigenesis and overexpression of p63 can enhance tumour growth and inhibit apoptosis. This review briefly summarises the roles of p63 in epithelial development, cellular proliferation, adhesion and migration and reveals its share in tumourigenesis and metastasis.
dcterms:title
p63 - an important player in epidermal and tumour development p63 - an important player in epidermal and tumour development
skos:prefLabel
p63 - an important player in epidermal and tumour development p63 - an important player in epidermal and tumour development
skos:notation
RIV/00209805:_____/12:#0000458!RIV14-GA0-00209805
n13:predkladatel
n14:ico%3A00209805
n4:aktivita
n7:P
n4:aktivity
P(ED2.1.00/03.0101), P(GPP301/10/P431), P(LM2010004)
n4:cisloPeriodika
Supplementum 2
n4:dodaniDat
n15:2014
n4:domaciTvurceVysledku
n5:9637419 Orzol, Paulina n5:3403149 n5:4001818
n4:druhVysledku
n11:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
163705
n4:idVysledku
RIV/00209805:_____/12:#0000458
n4:jazykVysledku
n10:eng
n4:klicovaSlova
p63; cell development; cell proliferation; cell adhesion; tumourigenesis; epidermis
n4:klicoveSlovo
n9:cell%20development n9:tumourigenesis n9:p63 n9:cell%20proliferation n9:epidermis n9:cell%20adhesion
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[EBEEDB005EFC]
n4:nazevZdroje
Klinická onkologie
n4:obor
n8:FD
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
4
n4:projekt
n6:GPP301%2F10%2FP431 n6:ED2.1.00%2F03.0101 n6:LM2010004
n4:rokUplatneniVysledku
n15:2012
n4:svazekPeriodika
25
n4:tvurceVysledku
Vojtěšek, Bořivoj Holčáková, Jitka Nekulová, Miroslava Orzol, Paulina
s:issn
0862-495X
s:numberOfPages
5