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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F12%3A%230000341%21RIV13-MZ0-00209805
rdf:type
skos:Concept n15:Vysledek
dcterms:description
MiRNA is extremely fast growing field, and miRNA knowledge is now believed to be a pivotal element of cancer biology. An individual miRNA interferes with a broad range of mRNAs; conversely, a single mRNA could be targeted by a variety of miRNAs. The complexity of miRNA:mRNA interaction is far-reaching and a bit beyond our understanding to date. It is already evident that the discovery of miRNA has created a paradigm shift in post-genomics biology, not only for scientists accustomed to traditional central dogma of molecular biology but also for researchers studying human diseases and accustomed to traditional genetics approach of studying one gene at the time. The ability of miRNAs to control large groups of genes and impose global post-transcriptional regulation of many (if not all) important cellular processes in development, cell proliferation and differentiation has opened up a new dimension and uncovered complexity of intracellular regulatory processes. This book is expected to provide introduction to the basic principles of miRNA biology, overview of miRNA significance in the hallmarks of cancer, experimental techniques used in miRNA research, and in special part - miRNAs importance in wide range of solid cancers with a special focus on its potential usage in molecular pathology, predictive oncology or as a novel therapeutic targets. MiRNA is extremely fast growing field, and miRNA knowledge is now believed to be a pivotal element of cancer biology. An individual miRNA interferes with a broad range of mRNAs; conversely, a single mRNA could be targeted by a variety of miRNAs. The complexity of miRNA:mRNA interaction is far-reaching and a bit beyond our understanding to date. It is already evident that the discovery of miRNA has created a paradigm shift in post-genomics biology, not only for scientists accustomed to traditional central dogma of molecular biology but also for researchers studying human diseases and accustomed to traditional genetics approach of studying one gene at the time. The ability of miRNAs to control large groups of genes and impose global post-transcriptional regulation of many (if not all) important cellular processes in development, cell proliferation and differentiation has opened up a new dimension and uncovered complexity of intracellular regulatory processes. This book is expected to provide introduction to the basic principles of miRNA biology, overview of miRNA significance in the hallmarks of cancer, experimental techniques used in miRNA research, and in special part - miRNAs importance in wide range of solid cancers with a special focus on its potential usage in molecular pathology, predictive oncology or as a novel therapeutic targets.
dcterms:title
MicroRNAs in solid cancer: from biomarkesrs to therapeutics targets MicroRNAs in solid cancer: from biomarkesrs to therapeutics targets
skos:prefLabel
MicroRNAs in solid cancer: from biomarkesrs to therapeutics targets MicroRNAs in solid cancer: from biomarkesrs to therapeutics targets
skos:notation
RIV/00209805:_____/12:#0000341!RIV13-MZ0-00209805
n15:predkladatel
n17:ico%3A00209805
n6:aktivita
n20:P
n6:aktivity
P(NS10352)
n6:dodaniDat
n7:2013
n6:domaciTvurceVysledku
n8:5974291
n6:druhVysledku
n11:B
n6:duvernostUdaju
n16:S
n6:entitaPredkladatele
n13:predkladatel
n6:idSjednocenehoVysledku
150385
n6:idVysledku
RIV/00209805:_____/12:#0000341
n6:jazykVysledku
n10:eng
n6:klicovaSlova
microRNAs; solid cancer; biomarkers; therapeutic targets
n6:klicoveSlovo
n9:microRNAs n9:therapeutic%20targets n9:solid%20cancer n9:biomarkers
n6:kontrolniKodProRIV
[42087C01FD14]
n6:mistoVydani
New York
n6:nazevZdroje
MicroRNAs in solid cancer: from biomarkesrs to therapeutics targets
n6:obor
n18:FD
n6:pocetDomacichTvurcuVysledku
1
n6:pocetStranKnihy
192
n6:pocetTvurcuVysledku
1
n6:projekt
n14:NS10352
n6:rokUplatneniVysledku
n7:2012
n6:tvurceVysledku
Slabý, Ondřej
s:numberOfPages
192
n5:hasPublisher
Nova Science Publishers
n12:isbn
978-1-61324-514-9