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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F12%3A%230000331%21RIV13-MSM-00209805
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://www.peterlang.com/index.cfm?cid=165#5500758
dcterms:description
The TP53 gene has a major role as an intgerator of cellular stresses and is commnly mutated or inactivated in human cancers. As well as inducing growth arrest and cell death by transcriptional activation of target genes after genotoxic stress, p53 also responds to hypoxia. Under hypoxic conditions, p53 acts largely as a transcriptional repressor but also enhancer HUF-1-mediated activation of apoptosis. Mutation to TP53 in tumours allows increased survival in hypoxia, suggesting that these pathways could be therapeutically useful. The two other members of the p53-family, p63 and p73, also influence hypoxic responses in poorly defined ways. The TP53 gene has a major role as an intgerator of cellular stresses and is commnly mutated or inactivated in human cancers. As well as inducing growth arrest and cell death by transcriptional activation of target genes after genotoxic stress, p53 also responds to hypoxia. Under hypoxic conditions, p53 acts largely as a transcriptional repressor but also enhancer HUF-1-mediated activation of apoptosis. Mutation to TP53 in tumours allows increased survival in hypoxia, suggesting that these pathways could be therapeutically useful. The two other members of the p53-family, p63 and p73, also influence hypoxic responses in poorly defined ways.
dcterms:title
Hypoxia and p53 Hypoxia and p53
skos:prefLabel
Hypoxia and p53 Hypoxia and p53
skos:notation
RIV/00209805:_____/12:#0000331!RIV13-MSM-00209805
n3:aktivita
n13:P n13:Z
n3:aktivity
P(ED2.1.00/03.0101), P(NT13794), Z(MZ0MOU2005)
n3:dodaniDat
n21:2013
n3:domaciTvurceVysledku
n9:1330586 n9:9637419 n9:5395488
n3:druhVysledku
n14:C
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
140146
n3:idVysledku
RIV/00209805:_____/12:#0000331
n3:jazykVysledku
n16:eng
n3:klicovaSlova
hypoxia; p53 protein family; TP53 gene; HIF; apoptosis; angiogenesis; chaperone
n3:klicoveSlovo
n6:HIF n6:p53%20protein%20family n6:TP53%20gene n6:apoptosis n6:hypoxia n6:angiogenesis n6:chaperone
n3:kontrolniKodProRIV
[C30169D61901]
n3:mistoVydani
Frankfurt am Main
n3:nazevZdroje
Tumour hypoxia: molecular mechanism and clinical implications
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetStranKnihy
556
n3:pocetTvurcuVysledku
4
n3:projekt
n8:ED2.1.00%2F03.0101 n8:NT13794
n3:rokUplatneniVysledku
n21:2012
n3:tvurceVysledku
Hrstka, Roman Vojtěšek, Bořivoj Müller, Petr
n3:zamer
n17:MZ0MOU2005
s:numberOfPages
24
n10:hasPublisher
Peter Lang
n15:isbn
978-3-631-63991-7