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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F12%3A%230000326%21RIV13-MSM-00209805
rdf:type
skos:Concept n9:Vysledek
dcterms:description
In 2009, the Nobel Prize in Physiology and Medicine has been awarded to Dr. Elizabeth H. Blackburn, Dr. Carol W. Greider and Dr. Jack W. Szostak „for the discovery how chromosomes are protected by telomeres and the enzyme telomerase“. A telomere is a region of repetitive nucleotide sequences at the end of the chromosome, which protecs the end of the chromosome from deterioration or from fusion with neighboring chromosomes in eucaryotic cells. A telomerase is an enzyme which adds DNA sequence repeats to the 3´end of DNA strands in the telomere regions and thus prevents from constant loss of informative DNA from chromosome ends during each replication cycle. Telomerase activity regulation and telomeres deterioration are implicated in various pathophysiological and clinical conditions. In 2009, the Nobel Prize in Physiology and Medicine has been awarded to Dr. Elizabeth H. Blackburn, Dr. Carol W. Greider and Dr. Jack W. Szostak „for the discovery how chromosomes are protected by telomeres and the enzyme telomerase“. A telomere is a region of repetitive nucleotide sequences at the end of the chromosome, which protecs the end of the chromosome from deterioration or from fusion with neighboring chromosomes in eucaryotic cells. A telomerase is an enzyme which adds DNA sequence repeats to the 3´end of DNA strands in the telomere regions and thus prevents from constant loss of informative DNA from chromosome ends during each replication cycle. Telomerase activity regulation and telomeres deterioration are implicated in various pathophysiological and clinical conditions.
dcterms:title
Telomeres, telomerase, an immortality Telomeres, telomerase, an immortality
skos:prefLabel
Telomeres, telomerase, an immortality Telomeres, telomerase, an immortality
skos:notation
RIV/00209805:_____/12:#0000326!RIV13-MSM-00209805
n9:predkladatel
n10:ico%3A00209805
n4:aktivita
n8:P
n4:aktivity
P(ED2.1.00/03.0101)
n4:cisloPeriodika
1
n4:dodaniDat
n13:2013
n4:domaciTvurceVysledku
n5:6595596
n4:druhVysledku
n17:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
173666
n4:idVysledku
RIV/00209805:_____/12:#0000326
n4:jazykVysledku
n15:eng
n4:klicovaSlova
chromosome; replication; telomere shortening
n4:klicoveSlovo
n7:telomere%20shortening n7:chromosome n7:replication
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[164870107BCF]
n4:nazevZdroje
Folia Mendeliana
n4:obor
n18:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
1
n4:projekt
n16:ED2.1.00%2F03.0101
n4:rokUplatneniVysledku
n13:2012
n4:svazekPeriodika
48
n4:tvurceVysledku
Zdražilová Dubská, Lenka
s:issn
0085-0748
s:numberOfPages
5