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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F12%3A%230000302%21RIV13-MSM-00209805
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://www.linkos.cz/files/klinicka-onkologie/174/4127.pdf
dcterms:description
Molecular chaperones (heat-shock proteins, Hsps) are proteins that maintain intracellular homeostasis through folding and stabilisation of the conformation of other proteins. Molecular chaperones are critical for survival of cells that undergo cellular stress due to their ability to guard the proteome against misfolded proteins and aggregation. In addition to their canonical role in basic cellular homeostasis and protection against external stress, several molecular chaperones play a fundamental role in malignant cell transformation. The level of molecular chaperones is increased in many solid tumours and haematological malignancies. The increased activity of Hsps in cancer cells reflects the ability of chaperones to compensate for stress caused by hypoxia, increased protein turnover and the presence of numerous mutated and potentially unstable proteins. In addition, chaperones allow tumour cells to tolerate genetic alterations by stabilising tertiary structure of mutated unstable proteins – typically oncoproteins that would otherwise be lethal. From this perspective, chaperones mediate the phenotypic expression of oncogenic mutations and contribute to all the hallmarks of cancer cells. Due to their indispensable roles for cancer cells, chaperones became an attractive group of targets for novel cancer therapies affecting several essential oncogenic pathways simultaneously. Molecular chaperones (heat-shock proteins, Hsps) are proteins that maintain intracellular homeostasis through folding and stabilisation of the conformation of other proteins. Molecular chaperones are critical for survival of cells that undergo cellular stress due to their ability to guard the proteome against misfolded proteins and aggregation. In addition to their canonical role in basic cellular homeostasis and protection against external stress, several molecular chaperones play a fundamental role in malignant cell transformation. The level of molecular chaperones is increased in many solid tumours and haematological malignancies. The increased activity of Hsps in cancer cells reflects the ability of chaperones to compensate for stress caused by hypoxia, increased protein turnover and the presence of numerous mutated and potentially unstable proteins. In addition, chaperones allow tumour cells to tolerate genetic alterations by stabilising tertiary structure of mutated unstable proteins – typically oncoproteins that would otherwise be lethal. From this perspective, chaperones mediate the phenotypic expression of oncogenic mutations and contribute to all the hallmarks of cancer cells. Due to their indispensable roles for cancer cells, chaperones became an attractive group of targets for novel cancer therapies affecting several essential oncogenic pathways simultaneously.
dcterms:title
The many roles of molecular chaperones and co-chaperones in tumour biology The many roles of molecular chaperones and co-chaperones in tumour biology
skos:prefLabel
The many roles of molecular chaperones and co-chaperones in tumour biology The many roles of molecular chaperones and co-chaperones in tumour biology
skos:notation
RIV/00209805:_____/12:#0000302!RIV13-MSM-00209805
n5:aktivita
n17:P
n5:aktivity
P(ED2.1.00/03.0101), P(GBP206/12/G151), P(NT13794)
n5:cisloPeriodika
supplementum 2
n5:dodaniDat
n7:2013
n5:domaciTvurceVysledku
n13:5395488 n13:9637419 Ďurech, Michal
n5:druhVysledku
n6:J
n5:duvernostUdaju
n15:S
n5:entitaPredkladatele
n18:predkladatel
n5:idSjednocenehoVysledku
148062
n5:idVysledku
RIV/00209805:_____/12:#0000302
n5:jazykVysledku
n12:eng
n5:klicovaSlova
molecular chaperones; co-chaperones; Hsp90; cancer
n5:klicoveSlovo
n9:cancer n9:co-chaperones n9:molecular%20chaperones n9:Hsp90
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[B78185E28242]
n5:nazevZdroje
Klinická onkologie
n5:obor
n16:FD
n5:pocetDomacichTvurcuVysledku
3
n5:pocetTvurcuVysledku
3
n5:projekt
n11:GBP206%2F12%2FG151 n11:ED2.1.00%2F03.0101 n11:NT13794
n5:rokUplatneniVysledku
n7:2012
n5:svazekPeriodika
25
n5:tvurceVysledku
Müller, Petr Vojtěšek, Bořivoj Ďurech, Michal
s:issn
0862-495X
s:numberOfPages
5