This HTML5 document contains 44 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n16http://linked.opendata.cz/resource/domain/vavai/projekt/
n10http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n9http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
rdfshttp://www.w3.org/2000/01/rdf-schema#
skoshttp://www.w3.org/2004/02/skos/core#
n14http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00209805%3A_____%2F12%3A%230000301%21RIV13-MSM-00209805/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n8http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n5http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F12%3A%230000301%21RIV13-MSM-00209805
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://www.linkos.cz/files/klinicka-onkologie/174/4125.pdf
dcterms:description
Both nascent and mature proteins are prone to damaging changes induced by either external or internal stimuli. Dysfunctional or misfolded proteins cause direct physiological risk in crowded cellular environment and must be readily and efficiently eliminated. To ensure protein homeostasis, eukaryotic cells have evolved several protein quality control machineries. Protein quality control plays a special role in cancer cells. Genetic instability causing increased production of damaged and/or deregulated proteins is a hallmark of cancer cells. Therefore, intrinsic genetic instability together with hostile tumour microenvironment represents a demanding task for protein quality control machineries in tumours. Regulation of general protein turnover as well as degradation of tumour-promoting/suppressing proteins by protein quality control machineries thus represent an important processes involved in cancer development and progression. The review focuses on the description of three major protein quality control pathways and their roles in cancer. Both nascent and mature proteins are prone to damaging changes induced by either external or internal stimuli. Dysfunctional or misfolded proteins cause direct physiological risk in crowded cellular environment and must be readily and efficiently eliminated. To ensure protein homeostasis, eukaryotic cells have evolved several protein quality control machineries. Protein quality control plays a special role in cancer cells. Genetic instability causing increased production of damaged and/or deregulated proteins is a hallmark of cancer cells. Therefore, intrinsic genetic instability together with hostile tumour microenvironment represents a demanding task for protein quality control machineries in tumours. Regulation of general protein turnover as well as degradation of tumour-promoting/suppressing proteins by protein quality control machineries thus represent an important processes involved in cancer development and progression. The review focuses on the description of three major protein quality control pathways and their roles in cancer.
dcterms:title
Protein quality control and cancerogenesis Protein quality control and cancerogenesis
skos:prefLabel
Protein quality control and cancerogenesis Protein quality control and cancerogenesis
skos:notation
RIV/00209805:_____/12:#0000301!RIV13-MSM-00209805
n4:aktivita
n7:P
n4:aktivity
P(ED2.1.00/03.0101), P(GBP206/12/G151), P(NT13794)
n4:cisloPeriodika
supplementum 2
n4:dodaniDat
n5:2013
n4:domaciTvurceVysledku
n10:5395488 n10:9637419 n10:3003221
n4:druhVysledku
n17:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
163058
n4:idVysledku
RIV/00209805:_____/12:#0000301
n4:jazykVysledku
n18:eng
n4:klicovaSlova
protein quality control (PQC); ubiquitination; endoplasmic reticulum; autophagy
n4:klicoveSlovo
n8:ubiquitination n8:autophagy n8:endoplasmic%20reticulum n8:protein%20quality%20control%20%28PQC%29
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[6FBB4D840A8D]
n4:nazevZdroje
Klinická onkologie
n4:obor
n11:FD
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
3
n4:projekt
n16:NT13794 n16:GBP206%2F12%2FG151 n16:ED2.1.00%2F03.0101
n4:rokUplatneniVysledku
n5:2012
n4:svazekPeriodika
25
n4:tvurceVysledku
Müller, Petr Vojtěšek, Bořivoj Trčka, Filip
s:issn
0862-495X
s:numberOfPages
7