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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F12%3A%230000299%21RIV13-MSM-00209805
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://www.linkos.cz/files/klinicka-onkologie/174/4121.pdf
dcterms:description
The prevailing aerobic glycolysis (so called Warburg effect) in cancer cells is according to current understanding the consequence of reprogramming of cellular metabolism during the process of malignant transformation. Metabolic regulation is inseparable component of cell proliferation machinery and has a tight link with activities of oncogenes and suppressor genes. The purpose of metabolic reprogramming of cancer (but also normal intensively proliferating cells) is to incorporate greater fraction of glucose metabolites into newly synthesised macromolecules. Apart from that, aerobic glycolysis confers several other selective advantages to cancer cells. Epidemiological data indicate that type 2 diabetes mellitus is associated with increased ncidence of several types of cancer and that cancer mortality can be influenced by ertain types of anti-diabetic treatment, however future research is needed to explain whether his relationship might be causal. Deeper knowledge about metabolic properties of rapidly proliferating cells can be exploited for further improvement of anti-cancer, immunosuppressive or anti-inflammatory therapies. The prevailing aerobic glycolysis (so called Warburg effect) in cancer cells is according to current understanding the consequence of reprogramming of cellular metabolism during the process of malignant transformation. Metabolic regulation is inseparable component of cell proliferation machinery and has a tight link with activities of oncogenes and suppressor genes. The purpose of metabolic reprogramming of cancer (but also normal intensively proliferating cells) is to incorporate greater fraction of glucose metabolites into newly synthesised macromolecules. Apart from that, aerobic glycolysis confers several other selective advantages to cancer cells. Epidemiological data indicate that type 2 diabetes mellitus is associated with increased ncidence of several types of cancer and that cancer mortality can be influenced by ertain types of anti-diabetic treatment, however future research is needed to explain whether his relationship might be causal. Deeper knowledge about metabolic properties of rapidly proliferating cells can be exploited for further improvement of anti-cancer, immunosuppressive or anti-inflammatory therapies.
dcterms:title
Cancer as a metabolic disease and diabetes as a precancerosis Cancer as a metabolic disease and diabetes as a precancerosis
skos:prefLabel
Cancer as a metabolic disease and diabetes as a precancerosis Cancer as a metabolic disease and diabetes as a precancerosis
skos:notation
RIV/00209805:_____/12:#0000299!RIV13-MSM-00209805
n10:predkladatel
n11:ico%3A00209805
n3:aktivita
n16:P
n3:aktivity
P(ED2.1.00/03.0101)
n3:cisloPeriodika
supplementum 2
n3:dodaniDat
n4:2013
n3:domaciTvurceVysledku
n13:1330586 n13:7988788
n3:druhVysledku
n15:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
125908
n3:idVysledku
RIV/00209805:_____/12:#0000299
n3:jazykVysledku
n14:eng
n3:klicovaSlova
diabetes; cancer; obesity; metabolism; glyoxalase; transketolase; p53; metformin
n3:klicoveSlovo
n6:transketolase n6:p53 n6:glyoxalase n6:metformin n6:cancer n6:metabolism n6:diabetes n6:obesity
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[1EE0C63262E7]
n3:nazevZdroje
Klinická onkologie
n3:obor
n8:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n5:ED2.1.00%2F03.0101
n3:rokUplatneniVysledku
n4:2012
n3:svazekPeriodika
25
n3:tvurceVysledku
Hrstka, Roman Kaňková, Kateřina
s:issn
0862-495X
s:numberOfPages
6