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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F12%3A%230000295%21RIV13-MSM-00209805
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://hmg.oxfordjournals.org/content/21/22/4980.full.pdf+html
dcterms:description
Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p216p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P 7.2 10(16)), 6p21 (P 2.3 10(14)) and 15q25 (P 2.2 10(63)). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16(INK4A)/p14(ARF)/CDKN2B/p15(INK4B)/ANRIL; rs1333040, P 3.0 10(7)) which was replicated in a series of 5415 Han Chinese (P 0.03; combined analysis, P 2.3 10(8)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer. Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p216p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P 7.2 10(16)), 6p21 (P 2.3 10(14)) and 15q25 (P 2.2 10(63)). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16(INK4A)/p14(ARF)/CDKN2B/p15(INK4B)/ANRIL; rs1333040, P 3.0 10(7)) which was replicated in a series of 5415 Han Chinese (P 0.03; combined analysis, P 2.3 10(8)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer.
dcterms:title
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
skos:prefLabel
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
skos:notation
RIV/00209805:_____/12:#0000295!RIV13-MSM-00209805
n7:predkladatel
n16:ico%3A00209805
n3:aktivita
n4:N n4:P n4:I
n3:aktivity
I, N, P(ED2.1.00/03.0101)
n3:cisloPeriodika
22
n3:dodaniDat
n14:2013
n3:domaciTvurceVysledku
n12:1030779
n3:druhVysledku
n20:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
141365
n3:idVysledku
RIV/00209805:_____/12:#0000295
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Genetic predisposition; Squamous cell carcinoma; SNP; Risk locus
n3:klicoveSlovo
n11:Risk%20locus n11:Genetic%20predisposition n11:Squamous%20cell%20carcinoma n11:SNP
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[8603EF0AC815]
n3:nazevZdroje
Human molecular genetics
n3:obor
n9:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
62
n3:projekt
n15:ED2.1.00%2F03.0101
n3:rokUplatneniVysledku
n14:2012
n3:svazekPeriodika
21
n3:tvurceVysledku
Foretová, Lenka Timofeeva, Maria N.
n3:wos
000310369000016
s:issn
0964-6906
s:numberOfPages
16
n17:doi
10.1093/hmg/dds334