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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F11%3A%230000242%21RIV12-MZ0-00209805
rdf:type
skos:Concept n5:Vysledek
rdfs:seeAlso
http://www.intechopen.com/books/rectal-cancer-a-multidisciplinary-approach-to-management
dcterms:description
Spontaneous rectal cancers usually arise as a consequence of somatic mutation of the APC gene followed by other mutations (K-ras mutation, DCC inactivation and p53 gene mutation), well-known today as the adenoma-to-carcinoma sequence (Kinzler & Vogelstein, 1996). This sequence covers most spontaneous rectal cancers (80%). However mutation(s) in DNA repair genes; the MSH1, MSH2, PMS1, PMS2 are also involved in certain fraction of rectal tumours, leading to microsatellite instability (Kim et al., 2006). Today about seventy different mutations, including important oncogenes and tumour suppressor genes, are known to be present in various colorectal cancers (Sjoblom, 2008). Colorectal cancers also exhibit changes in DNA methylation with hypermethylation of CpG islands and hypomethylation of oncogenes (Kang, 2007). The mutated cancer genotype is associated with changed expression in many genes, as has been demonstrated by powerful microarray analysis and Real Time PCR technology. It is now well known that mutations and changed DNA methylation pattern, as well as changes of mRNA transcription, are accompanied by changes of expression in certain microRNAs. Spontaneous rectal cancers usually arise as a consequence of somatic mutation of the APC gene followed by other mutations (K-ras mutation, DCC inactivation and p53 gene mutation), well-known today as the adenoma-to-carcinoma sequence (Kinzler & Vogelstein, 1996). This sequence covers most spontaneous rectal cancers (80%). However mutation(s) in DNA repair genes; the MSH1, MSH2, PMS1, PMS2 are also involved in certain fraction of rectal tumours, leading to microsatellite instability (Kim et al., 2006). Today about seventy different mutations, including important oncogenes and tumour suppressor genes, are known to be present in various colorectal cancers (Sjoblom, 2008). Colorectal cancers also exhibit changes in DNA methylation with hypermethylation of CpG islands and hypomethylation of oncogenes (Kang, 2007). The mutated cancer genotype is associated with changed expression in many genes, as has been demonstrated by powerful microarray analysis and Real Time PCR technology. It is now well known that mutations and changed DNA methylation pattern, as well as changes of mRNA transcription, are accompanied by changes of expression in certain microRNAs.
dcterms:title
MicroRNAs and rectal cancer MicroRNAs and rectal cancer
skos:prefLabel
MicroRNAs and rectal cancer MicroRNAs and rectal cancer
skos:notation
RIV/00209805:_____/11:#0000242!RIV12-MZ0-00209805
n5:predkladatel
n6:ico%3A00209805
n3:aktivita
n15:I
n3:aktivity
I
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n10:4160584
n3:druhVysledku
n7:C
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
212339
n3:idVysledku
RIV/00209805:_____/11:#0000242
n3:jazykVysledku
n20:eng
n3:klicovaSlova
rectal cancer; microRNA
n3:klicoveSlovo
n4:microRNA n4:rectal%20cancer
n3:kontrolniKodProRIV
[0C735E90FEB7]
n3:mistoVydani
Rijeka
n3:nazevZdroje
Rectal cancer - a multidisciplinary approach to management
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetStranKnihy
420
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n12:2011
n3:tvurceVysledku
Svoboda, Miroslav Kocáková, Ilona
s:numberOfPages
22
n16:hasPublisher
InTech
n19:isbn
978-953-307-758-1