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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F11%3A%230000173%21RIV12-MZ0-00209805
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020432
dcterms:description
Background: Epidemiologic studies are reporting associations between lead exposure and human cancers. A polymorphism in the 5-aminolevulinic acid dehydratase (ALAD) gene affects lead toxicokinetics and may modify the adverse effects of lead. Methods: The objective of this study was to evaluate single-nucleotide polymorphisms (SNPs) tagging the ALAD region among renal cancer cases and controls to determine whether genetic variation alters the relationship between lead and renal cancer. Occupational exposure to lead and risk of cancer was examined in a case-control study of renal cell carcinoma (RCC). Comprehensive analysis of variation across the ALAD gene was assessed using a tagging SNP approach among 987 cases and 1298 controls. Occupational lead exposure was estimated using questionnaire-based exposure assessment and expert review. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression. Results: The adjusted risk associated with the ALAD variant rs8177796(CT/TT) was increased (OR = 1.35, 95%CI = 1.05-1.73, p-value = 0.02) when compared to the major allele, regardless of lead exposure. Joint effects of lead and ALAD rs2761016 suggest an increased RCC risk for the homozygous wild-type and heterozygous alleles ((OR)-O-GG = 2.68, 95%CI = 1.17-6.12, p = 0.01; (OR)-O-GA = 1.79, 95%CI = 1.06-3.04 with an interaction approaching significance (p(int) = 0.06).. No significant modification in RCC risk was observed for the functional variant rs1800435((K68N)). Haplotype analysis identified a region associated with risk supporting tagging SNP results. Conclusion: A common genetic variation in ALAD may alter the risk of RCC overall, and among individuals occupationally exposed to lead. Further work in larger exposed populations is warranted to determine if ALAD modifies RCC risk associated with lead exposure. Background: Epidemiologic studies are reporting associations between lead exposure and human cancers. A polymorphism in the 5-aminolevulinic acid dehydratase (ALAD) gene affects lead toxicokinetics and may modify the adverse effects of lead. Methods: The objective of this study was to evaluate single-nucleotide polymorphisms (SNPs) tagging the ALAD region among renal cancer cases and controls to determine whether genetic variation alters the relationship between lead and renal cancer. Occupational exposure to lead and risk of cancer was examined in a case-control study of renal cell carcinoma (RCC). Comprehensive analysis of variation across the ALAD gene was assessed using a tagging SNP approach among 987 cases and 1298 controls. Occupational lead exposure was estimated using questionnaire-based exposure assessment and expert review. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression. Results: The adjusted risk associated with the ALAD variant rs8177796(CT/TT) was increased (OR = 1.35, 95%CI = 1.05-1.73, p-value = 0.02) when compared to the major allele, regardless of lead exposure. Joint effects of lead and ALAD rs2761016 suggest an increased RCC risk for the homozygous wild-type and heterozygous alleles ((OR)-O-GG = 2.68, 95%CI = 1.17-6.12, p = 0.01; (OR)-O-GA = 1.79, 95%CI = 1.06-3.04 with an interaction approaching significance (p(int) = 0.06).. No significant modification in RCC risk was observed for the functional variant rs1800435((K68N)). Haplotype analysis identified a region associated with risk supporting tagging SNP results. Conclusion: A common genetic variation in ALAD may alter the risk of RCC overall, and among individuals occupationally exposed to lead. Further work in larger exposed populations is warranted to determine if ALAD modifies RCC risk associated with lead exposure.
dcterms:title
Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead
skos:prefLabel
Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead
skos:notation
RIV/00209805:_____/11:#0000173!RIV12-MZ0-00209805
n12:predkladatel
n13:ico%3A00209805
n3:aktivita
n14:V n14:I n14:N
n3:aktivity
I, N, V
n3:cisloPeriodika
7
n3:dodaniDat
n5:2012
n3:domaciTvurceVysledku
n6:5859565
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
191463
n3:idVysledku
RIV/00209805:_____/11:#0000173
n3:jazykVysledku
n19:eng
n3:klicovaSlova
aminolevulinate dehydratase polymorphism; blood lead; genetic susceptibility; kidney cancer; workers; population; porphyria; smoking
n3:klicoveSlovo
n4:genetic%20susceptibility n4:aminolevulinate%20dehydratase%20polymorphism n4:smoking n4:population n4:kidney%20cancer n4:porphyria n4:blood%20lead n4:workers
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A956EDF63DA2]
n3:nazevZdroje
PloS one
n3:obor
n15:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
23
n3:rokUplatneniVysledku
n5:2011
n3:svazekPeriodika
6
n3:tvurceVysledku
Navrátilová, Marie van Bemmel, Dana M.
n3:wos
000292931200002
s:issn
1932-6203
s:numberOfPages
7
n18:doi
10.1371/journal.pone.0020432