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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F11%3A%230000147%21RIV12-MSM-00209805
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://www.springerlink.com/content/9801w775x3587419/?MUD=MP
dcterms:description
The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy. The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy.
dcterms:title
The role of p63 in cancer, stem cells and cancer stem cells The role of p63 in cancer, stem cells and cancer stem cells
skos:prefLabel
The role of p63 in cancer, stem cells and cancer stem cells The role of p63 in cancer, stem cells and cancer stem cells
skos:notation
RIV/00209805:_____/11:#0000147!RIV12-MSM-00209805
n9:predkladatel
n10:ico%3A00209805
n3:aktivita
n15:P n15:Z
n3:aktivity
P(ED2.1.00/03.0101), P(GPP301/10/P431), Z(MZ0MOU2005)
n3:cisloPeriodika
2
n3:dodaniDat
n18:2012
n3:domaciTvurceVysledku
n12:4001818 n12:3403149 n12:9637419
n3:druhVysledku
n16:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
227496
n3:idVysledku
RIV/00209805:_____/11:#0000147
n3:jazykVysledku
n4:eng
n3:klicovaSlova
p63; TAp63; ΔNp63; p53 family; cancer; stem cells
n3:klicoveSlovo
n6:p53%20family n6:cancer n6:TAp63 n6:stem%20cells n6:%CE%94Np63 n6:p63
n3:kodStatuVydavatele
PL - Polská republika
n3:kontrolniKodProRIV
[2D50F80FEF34]
n3:nazevZdroje
Cellular and molecular biology letters
n3:obor
n17:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n11:ED2.1.00%2F03.0101 n11:GPP301%2F10%2FP431
n3:rokUplatneniVysledku
n18:2011
n3:svazekPeriodika
16
n3:tvurceVysledku
Holčáková, Jitka Nekulová, Marta Vojtěšek, Bořivoj
n3:wos
000288798300008
n3:zamer
n13:MZ0MOU2005
s:issn
1425-8153
s:numberOfPages
32
n20:doi
10.2478/s11658-011-0009-9