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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F10%3A%230000259%21RIV12-MZ0-00209805
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://carcin.oxfordjournals.org/content/31/4/625
dcterms:description
Background. Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancer-related pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3). Methods. Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk. Results. Only the association between a non-synonymous variant of TP53BP1 (rs560191) and lung cancer risk was significant (OR = 0.91, P = 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86, P = 6 x 10(-4)). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11 722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89-0.97) (P = 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85-0.95), P = 1 x 10(-4)]. Conclusion. This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations. Background. Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancer-related pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3). Methods. Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk. Results. Only the association between a non-synonymous variant of TP53BP1 (rs560191) and lung cancer risk was significant (OR = 0.91, P = 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86, P = 6 x 10(-4)). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11 722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89-0.97) (P = 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85-0.95), P = 1 x 10(-4)]. Conclusion. This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.
dcterms:title
International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants
skos:prefLabel
International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants
skos:notation
RIV/00209805:_____/10:#0000259!RIV12-MZ0-00209805
n3:aktivita
n12:V n12:I n12:R
n3:aktivity
I, R, V
n3:cisloPeriodika
4
n3:dodaniDat
n17:2012
n3:domaciTvurceVysledku
n4:1030779
n3:druhVysledku
n15:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
264550
n3:idVysledku
RIV/00209805:_____/10:#0000259
n3:jazykVysledku
n9:eng
n3:klicovaSlova
methylene-tetrahydrofolate reductase; gene polymorphisms; Chinese population; sequence variants; cell; Central Europe
n3:klicoveSlovo
n5:gene%20polymorphisms n5:cell n5:sequence%20variants n5:methylene-tetrahydrofolate%20reductase n5:Central%20Europe n5:Chinese%20population
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[293D69D9FDDD]
n3:nazevZdroje
Carcinogenesis
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
52
n3:rokUplatneniVysledku
n17:2010
n3:svazekPeriodika
31
n3:tvurceVysledku
Foretová, Lenka Brennan, Paul
n3:wos
000276285200012
s:issn
0143-3334
s:numberOfPages
9
n8:doi
10.1093/carcin/bgq001