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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F10%3A%230000257%21RIV12-MZ0-00209805
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://aje.oxfordjournals.org/content/171/3/267
dcterms:description
In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF -308G > A (rs1800629), lymphotoxin-alpha (LTA) 252A > G (rs909253), IL10 -3575T > A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for %22new%22 participant TNF -308A carriers (NHL: per-allele odds ratio (OR(allelic)) = 1.10, P(trend) = 0.001; diffuse large B-cell lymphoma (DLBCL): OR(allelic) = 1.23, P(trend) = 0.004). In the combined population, odds ratios were increased for TNF -308A carriers (NHL: OR(allelic) = 1.13, P(trend) = 0.0001; DLBCL: OR(allelic) = 1.25, P(trend) = 3.7 x 10(-6); marginal zone lymphoma: OR(allelic) = 1.35, P(trend) = 0.004) and LTA 252G carriers (DLBCL: OR(allelic) = 1.12, P(trend) = 0.006; mycosis fungoides: OR(allelic) = 1.44, P(trend) = 0.015). The LTA 252A > G/TNF -308G > A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P = 2.9 x 10(-8)). Results suggested associations between IL10 -3575T > A and DLBCL (P(trend) = 0.02) and IL10 -1082A > G and mantle cell lymphoma (P(trend) = 0.04). These findings strengthen previous results for DLBCL and the LTA 252A > G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology. In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF -308G > A (rs1800629), lymphotoxin-alpha (LTA) 252A > G (rs909253), IL10 -3575T > A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for %22new%22 participant TNF -308A carriers (NHL: per-allele odds ratio (OR(allelic)) = 1.10, P(trend) = 0.001; diffuse large B-cell lymphoma (DLBCL): OR(allelic) = 1.23, P(trend) = 0.004). In the combined population, odds ratios were increased for TNF -308A carriers (NHL: OR(allelic) = 1.13, P(trend) = 0.0001; DLBCL: OR(allelic) = 1.25, P(trend) = 3.7 x 10(-6); marginal zone lymphoma: OR(allelic) = 1.35, P(trend) = 0.004) and LTA 252G carriers (DLBCL: OR(allelic) = 1.12, P(trend) = 0.006; mycosis fungoides: OR(allelic) = 1.44, P(trend) = 0.015). The LTA 252A > G/TNF -308G > A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P = 2.9 x 10(-8)). Results suggested associations between IL10 -3575T > A and DLBCL (P(trend) = 0.02) and IL10 -1082A > G and mantle cell lymphoma (P(trend) = 0.04). These findings strengthen previous results for DLBCL and the LTA 252A > G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology.
dcterms:title
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium
skos:prefLabel
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium
skos:notation
RIV/00209805:_____/10:#0000257!RIV12-MZ0-00209805
n4:aktivita
n11:I
n4:aktivity
I
n4:cisloPeriodika
3
n4:dodaniDat
n12:2012
n4:domaciTvurceVysledku
n14:1030779
n4:druhVysledku
n13:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
293732
n4:idVysledku
RIV/00209805:_____/10:#0000257
n4:jazykVysledku
n15:eng
n4:klicovaSlova
non-Hodgkin lymphoma; lymphotoxin-alpha; meta-analysis; polymorphism; genetic; tumor necrosis factor-alpha; single nucleotide
n4:klicoveSlovo
n6:polymorphism n6:single%20nucleotide n6:meta-analysis n6:tumor%20necrosis%20factor-alpha n6:lymphotoxin-alpha n6:genetic n6:non-Hodgkin%20lymphoma
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[3A89003BCE89]
n4:nazevZdroje
American journal of epidemiology
n4:obor
n10:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
42
n4:rokUplatneniVysledku
n12:2010
n4:svazekPeriodika
171
n4:tvurceVysledku
Skibola, Christina F. Foretová, Lenka
n4:wos
000273866000001
s:issn
0002-9262
s:numberOfPages
10
n17:doi
10.1093/aje/kwp383