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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F10%3A%230000135%21RIV11-MZ0-00209805
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Hereditary cancer syndromes are frequently seen in young cancer patients and patients with a positive family history. Genetic testing is important for the identifi cation of high-risk individuals, and for the early introduction of specialized preventive care or prophylactic surgeries. High-risk tumour suppressor genes (BRCA1 and BRCA2) and DNA repair genes (MLH1, MSH2 and MSH6) are responsible for a substantial part of hereditary breast, ovarian and colorectal cancer. Other hereditary cancers are seen less frequently, but genetic testing has increased for many other site-specifi c cancers and complex syndromes. Hereditary cancer syndromes are frequently seen in young cancer patients and patients with a positive family history. Genetic testing is important for the identifi cation of high-risk individuals, and for the early introduction of specialized preventive care or prophylactic surgeries. High-risk tumour suppressor genes (BRCA1 and BRCA2) and DNA repair genes (MLH1, MSH2 and MSH6) are responsible for a substantial part of hereditary breast, ovarian and colorectal cancer. Other hereditary cancers are seen less frequently, but genetic testing has increased for many other site-specifi c cancers and complex syndromes.
dcterms:title
Genetic testing and prevention of hereditary cancer at the MMCI – over 10 years of experience Genetic testing and prevention of hereditary cancer at the MMCI – over 10 years of experience
skos:prefLabel
Genetic testing and prevention of hereditary cancer at the MMCI – over 10 years of experience Genetic testing and prevention of hereditary cancer at the MMCI – over 10 years of experience
skos:notation
RIV/00209805:_____/10:#0000135!RIV11-MZ0-00209805
n4:aktivita
n12:Z n12:P
n4:aktivity
P(NS10357), P(NS10536), Z(MZ0MOU2005)
n4:cisloPeriodika
6
n4:dodaniDat
n6:2011
n4:domaciTvurceVysledku
n5:7563663 n5:9872809 n5:3010988 n5:1030779 n5:7816766 n5:1758284 n5:2239914 n5:6491286 n5:7470126 n5:5859565 n5:6760074 n5:4585798
n4:druhVysledku
n14:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
260415
n4:idVysledku
RIV/00209805:_____/10:#0000135
n4:jazykVysledku
n18:eng
n4:klicovaSlova
hereditary cancer, syndromes, genetic testing, prevention
n4:klicoveSlovo
n8:hereditary%20cancer n8:syndromes n8:prevention n8:genetic%20testing
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[DCFBD2F8B4CD]
n4:nazevZdroje
Klinická onkologie
n4:obor
n16:FD
n4:pocetDomacichTvurcuVysledku
12
n4:pocetTvurcuVysledku
14
n4:projekt
n15:NS10357 n15:NS10536
n4:rokUplatneniVysledku
n6:2010
n4:svazekPeriodika
23
n4:tvurceVysledku
Navrátilová, Marie Kalábová, Renata Bolčák, Karol Foretová, Lenka Vašíčková, Petra Krejčí, Eva Schneiderová, Monika Macháčková, Eva Palácová, Markéta Petráková, Katarína Svoboda, Marek Házová, Jana
n4:zamer
n17:MZ0MOU2005
s:issn
0862-495X
s:numberOfPages
3