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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F04%3A00013645%21RIV%2F2005%2FMZ0%2FL26005%2FN
rdf:type
skos:Concept n16:Vysledek
dcterms:description
For decades it has been well known that elevated levels of homocysteine are harmful to humans on the basis of clinical observations derived from classical model diseases, such as inherited metabolic disorders. This group of diseases includes classical homocystinuria and several other inherited diseases affecting the so-called 'transsulfuration pathways'. Homocysteine lies in a metabolic checkpoint that interconnects one-carbon-transferring reactions with metabolism of sulfur-containing amino acids, since every molecule of 5-methyltetrahydrofolate derived either from plasma or generated from other folate species must be demethylated to liberate the reduced tetrahydrofolate. This unidirectional mechanism operates in every cell and has no alternative in eukaryotic cells. Antifolates are a group of anticancer agents targeting various metabolic steps within folate metabolism. They exert an indirect influence on the rate of appearance/disappearance of homocysteine from cellular and plasma compartments. Rece Poruchy metabolismu homocyteinu jsou v medicíně známy desítky let, jako vrozené choroby. Tato skupina chorob zahrnuje klasickou cystinurii i další transsulfurační poruchy, kde se jedná vždy o demethylaci a uvolnění redukovaného tetrahydrofolátu. Antifoláty jsou cytostatika atakující různé kroky folátového metabolismu a ovlivňují metabolismus homocysteinu v buňce i plasmě. To se projeví také u terapie methotrexatem a tato role je nyní aktuálně studována . V klinické praxi jsou studovány genetické poruchy metabolismu folátů a homocysteinu z hlediska farmakologie i famakogenetiky. Práce navrhuje možné cesty užití homocysteinu jako biomarkeru antifolátové terapie. For decades it has been well known that elevated levels of homocysteine are harmful to humans on the basis of clinical observations derived from classical model diseases, such as inherited metabolic disorders. This group of diseases includes classical homocystinuria and several other inherited diseases affecting the so-called 'transsulfuration pathways'. Homocysteine lies in a metabolic checkpoint that interconnects one-carbon-transferring reactions with metabolism of sulfur-containing amino acids, since every molecule of 5-methyltetrahydrofolate derived either from plasma or generated from other folate species must be demethylated to liberate the reduced tetrahydrofolate. This unidirectional mechanism operates in every cell and has no alternative in eukaryotic cells. Antifolates are a group of anticancer agents targeting various metabolic steps within folate metabolism. They exert an indirect influence on the rate of appearance/disappearance of homocysteine from cellular and plasma compartments. Rece
dcterms:title
Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy Homocystein: využití jako farmakodynamický biomarker antifolátové chemoterapie
skos:prefLabel
Homocystein: využití jako farmakodynamický biomarker antifolátové chemoterapie Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy
skos:notation
RIV/00209805:_____/04:00013645!RIV/2005/MZ0/L26005/N
n3:strany
1151; 1162
n3:aktivita
n10:P
n3:aktivity
P(NC7104)
n3:cisloPeriodika
8
n3:dodaniDat
n5:2005
n3:domaciTvurceVysledku
n11:2486725
n3:druhVysledku
n4:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
566621
n3:idVysledku
RIV/00209805:_____/04:00013645
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Antimetabolites, antineoplastic;biological markers;folic acid antagonists;homocysteine;methotrexate
n3:klicoveSlovo
n6:homocysteine n6:Antimetabolites n6:biological%20markers n6:antineoplastic n6:methotrexate n6:folic%20acid%20antagonists
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[36E12B7CF8C1]
n3:nazevZdroje
Pharmacogenomics
n3:obor
n9:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n15:NC7104
n3:rokUplatneniVysledku
n5:2004
n3:svazekPeriodika
5
n3:tvurceVysledku
Valík, Dalibor
s:issn
1462-2416
s:numberOfPages
12