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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F03%3A00008209%21RIV%2F2004%2FGA0%2FL26004%2FN
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Using immunoprecipitation and Western blots performed on lysates made of melanoma cells derived from patients with clinical stage II/III and employing specific anti-STAT 1 PS 727/PY 701 immunoprobes, we show that STAT 1 activation response induced by IFN-alfa/-gamma is significantly impaired. In average, three quarters of patients were lacking phosphorylation at S 727. STAT 1 PY 701 was not inducible by IFN-alfa in 63% and by IFN-gamma in 34% of samples However, these STAT 1 activation defects showed no correlation with the disease outcome and immunotherapy response as indicated by progression-free survival profiles in patients treated with IFN-alfa2b. Using immunoprecipitation and Western blots performed on lysates made of melanoma cells derived from patients with clinical stage II/III and employing specific anti-STAT 1 PS 727/PY 701 immunoprobes, we show that STAT 1 activation response induced by IFN-alfa/-gamma is significantly impaired. In average, three quarters of patients were lacking phosphorylation at S 727. STAT 1 PY 701 was not inducible by IFN-alfa in 63% and by IFN-gamma in 34% of samples However, these STAT 1 activation defects showed no correlation with the disease outcome and immunotherapy response as indicated by progression-free survival profiles in patients treated with IFN-alfa2b.
dcterms:title
Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients
skos:prefLabel
Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients
skos:notation
RIV/00209805:_____/03:00008209!RIV/2004/GA0/L26004/N
n3:strany
142; 146
n3:aktivita
n16:Z n16:P
n3:aktivity
P(GA301/00/0564), P(NC7139), Z(MZ00020980501)
n3:cisloPeriodika
4
n3:dodaniDat
n10:2004
n3:domaciTvurceVysledku
n12:3251993 n12:7705395
n3:druhVysledku
n18:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
610906
n3:idVysledku
RIV/00209805:_____/03:00008209
n3:jazykVysledku
n17:eng
n3:klicovaSlova
STAT 1;malignant melanoma;signal transduction;interferons
n3:klicoveSlovo
n8:signal%20transduction n8:interferons n8:malignant%20melanoma n8:STAT%201
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[9C1073143088]
n3:nazevZdroje
Folia Biologica
n3:obor
n6:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n15:NC7139 n15:GA301%2F00%2F0564
n3:rokUplatneniVysledku
n10:2003
n3:svazekPeriodika
49
n3:tvurceVysledku
Kovařík, Jan Boudný, Vladimír
n3:zamer
n9:MZ00020980501
s:issn
0015-5500
s:numberOfPages
5