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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F03%3A00007944%21RIV%2F2004%2FMZ0%2FL26004%2FN
rdf:type
n8:Vysledek skos:Concept
dcterms:description
The TP73 gene is a member of the p53 family and through differential promoter usage and alternative splicing can encode a number of different isoforms that have distinct properties. In particular, we found that invasive islands lose p73alpha expression when compared with the overlying intraepithelial lesion. These results show a tight regulation of p73 isoform expression in cervical epithelium and imply that different isoforms of p73 enhance or suppress neoplastic cell growth. These data raise the possibility that reactivation of p73alpha might be beneficial in cervical carcinoma. The TP73 gene is a member of the p53 family and through differential promoter usage and alternative splicing can encode a number of different isoforms that have distinct properties. In particular, we found that invasive islands lose p73alpha expression when compared with the overlying intraepithelial lesion. These results show a tight regulation of p73 isoform expression in cervical epithelium and imply that different isoforms of p73 enhance or suppress neoplastic cell growth. These data raise the possibility that reactivation of p73alpha might be beneficial in cervical carcinoma.
dcterms:title
Differential expression of p73alpha in normal ectocervical epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma Differential expression of p73alpha in normal ectocervical epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma
skos:prefLabel
Differential expression of p73alpha in normal ectocervical epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma Differential expression of p73alpha in normal ectocervical epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma
skos:notation
RIV/00209805:_____/03:00007944!RIV/2004/MZ0/L26004/N
n4:strany
386; 392
n4:aktivita
n7:P
n4:aktivity
P(NC6404)
n4:cisloPeriodika
4
n4:dodaniDat
n10:2004
n4:domaciTvurceVysledku
n5:5713021 n5:9637419
n4:druhVysledku
n16:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
603862
n4:idVysledku
RIV/00209805:_____/03:00007944
n4:jazykVysledku
n12:eng
n4:klicovaSlova
p73;Squamous cell carcinoma;Sterine cervix
n4:klicoveSlovo
n6:Sterine%20cervix n6:Squamous%20cell%20carcinoma n6:p73
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[6433A8F82EF0]
n4:nazevZdroje
International journal of gynecological pathology
n4:obor
n13:FD
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
5
n4:projekt
n14:NC6404
n4:rokUplatneniVysledku
n10:2003
n4:svazekPeriodika
22
n4:tvurceVysledku
Vojtěšek, Bořivoj Nenutil, Rudolf
s:issn
0277-1691
s:numberOfPages
7