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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F12%3A10133779%21RIV13-MZ0-00179906
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.4149/neo_2012_063
dcterms:description
Intraoperative placement of catheters in the tumor bed during breast-conserving surgery (BCS) enables postponed targeted boost irradiation in high risk breast cancer patients. Twenty-three patients with high risk breast cancer underwent neoadjuvant chemotherapy and multifractionated perioperative brachytherapy as a boost to the tumor bed using three-dimensional (3D) CT-based planning. Plastic catheters for brachytherapy were implanted during surgery and targeted irradiation was delivered in the course of 2-3 weeks. Acute and late toxicities were scored according to the RTOG Common Toxicity Criteria. Cosmetic outcomes were assessed using the Harvard criteria. No major perioperative complications were recorded. Circumscribed wound infection occurred in one patient (4.3%). Only 3 patients (13%) experienced acute skin toxicity Grade 1. We observed no teleangiectasias or pigmentations. The cosmetic outcome at last follow-up visit was rated as excellent/good, in 82.6%, fair, in 13% and poor in 4.4% of patients, respectively. There was no evidence of disease recurrence after median follow-up of 43. 4 months. Systematic integration of the perioperative fractionated 3D CT-based HDR brachytherapy as a boost for patients with breast cancer after BCS is feasible and seems safe. It might be beneficial especially for women with high risk of local recurrence. Intraoperative placement of catheters in the tumor bed during breast-conserving surgery (BCS) enables postponed targeted boost irradiation in high risk breast cancer patients. Twenty-three patients with high risk breast cancer underwent neoadjuvant chemotherapy and multifractionated perioperative brachytherapy as a boost to the tumor bed using three-dimensional (3D) CT-based planning. Plastic catheters for brachytherapy were implanted during surgery and targeted irradiation was delivered in the course of 2-3 weeks. Acute and late toxicities were scored according to the RTOG Common Toxicity Criteria. Cosmetic outcomes were assessed using the Harvard criteria. No major perioperative complications were recorded. Circumscribed wound infection occurred in one patient (4.3%). Only 3 patients (13%) experienced acute skin toxicity Grade 1. We observed no teleangiectasias or pigmentations. The cosmetic outcome at last follow-up visit was rated as excellent/good, in 82.6%, fair, in 13% and poor in 4.4% of patients, respectively. There was no evidence of disease recurrence after median follow-up of 43. 4 months. Systematic integration of the perioperative fractionated 3D CT-based HDR brachytherapy as a boost for patients with breast cancer after BCS is feasible and seems safe. It might be beneficial especially for women with high risk of local recurrence.
dcterms:title
Perioperative interstitial CT-based brachytherapy boost in breast cancer patients with breast conservation after neoadjuvant chemotherapy Perioperative interstitial CT-based brachytherapy boost in breast cancer patients with breast conservation after neoadjuvant chemotherapy
skos:prefLabel
Perioperative interstitial CT-based brachytherapy boost in breast cancer patients with breast conservation after neoadjuvant chemotherapy Perioperative interstitial CT-based brachytherapy boost in breast cancer patients with breast conservation after neoadjuvant chemotherapy
skos:notation
RIV/00179906:_____/12:10133779!RIV13-MZ0-00179906
n12:predkladatel
n17:ico%3A00179906
n3:aktivita
n5:I
n3:aktivity
I
n3:cisloPeriodika
5
n3:dodaniDat
n8:2013
n3:domaciTvurceVysledku
n18:7177364
n3:druhVysledku
n19:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
158259
n3:idVysledku
RIV/00179906:_____/12:10133779
n3:jazykVysledku
n9:eng
n3:klicovaSlova
target volume; local control; intraoperative radiotherapy; breast cancer; boost; brachytherapy
n3:klicoveSlovo
n6:local%20control n6:boost n6:brachytherapy n6:intraoperative%20radiotherapy n6:target%20volume n6:breast%20cancer
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[516AE0A5345C]
n3:nazevZdroje
Neoplasma
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n8:2012
n3:svazekPeriodika
59
n3:tvurceVysledku
Šťastný, K. Jalcová, L. Doležel, M. Kolářová, I. Dvořáková, D. Kroulík, T. Vaňásek, J. Kohlová, Tereza Odrážka, K.
n3:wos
000307860500003
s:issn
0028-2685
s:numberOfPages
6
n14:doi
10.4149/neo_2012_063