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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F12%3A10125393%21RIV13-MZ0-00179906
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Regulatory T cells (Treg) are a specialized subpopulation of T cells that act to suppress inadequate immune response. Psoriasis is recognized as a T cell driven immune-mediated systemic inflammatory disease wit skin manifestation. Effective therapeutical approach to treat psoriasis is Goeckerman therapy (GT). The aim of this study was to compare the number of Treg in the peripheral blood of 27 psoriatic patients and 19 controls and to evaluate the influence of GT on Treg population in peripheral blood of patients with psoriasis. There was no significant difference in the relative number of Treg cells in the peripheral blood of healthy blood donors and patients with psoriasis before initiation of GT (P = 0.2668). In contrary, the relative number of Treg cells in peripheral blood of patients with psoriasis after GT was significantly higher than those found in healthy blood donors (P = 0.0019). Moreover, the relative number of Treg is significantly increased in psoriatic patients after Goeckerman therapy compared to the pre-treatment level (P = 0.0042). In conclusion, this significant increase in Treg count after GT is probably associated with amelioration of inflammation by GT, as disease activity expressed as PASI decreased in our patients by GT (P = 0.0001). Regulatory T cells (Treg) are a specialized subpopulation of T cells that act to suppress inadequate immune response. Psoriasis is recognized as a T cell driven immune-mediated systemic inflammatory disease wit skin manifestation. Effective therapeutical approach to treat psoriasis is Goeckerman therapy (GT). The aim of this study was to compare the number of Treg in the peripheral blood of 27 psoriatic patients and 19 controls and to evaluate the influence of GT on Treg population in peripheral blood of patients with psoriasis. There was no significant difference in the relative number of Treg cells in the peripheral blood of healthy blood donors and patients with psoriasis before initiation of GT (P = 0.2668). In contrary, the relative number of Treg cells in peripheral blood of patients with psoriasis after GT was significantly higher than those found in healthy blood donors (P = 0.0019). Moreover, the relative number of Treg is significantly increased in psoriatic patients after Goeckerman therapy compared to the pre-treatment level (P = 0.0042). In conclusion, this significant increase in Treg count after GT is probably associated with amelioration of inflammation by GT, as disease activity expressed as PASI decreased in our patients by GT (P = 0.0001).
dcterms:title
The number of immunoregulatory T cells is increased in patients with psoriasis after Goeckerman therapy The number of immunoregulatory T cells is increased in patients with psoriasis after Goeckerman therapy
skos:prefLabel
The number of immunoregulatory T cells is increased in patients with psoriasis after Goeckerman therapy The number of immunoregulatory T cells is increased in patients with psoriasis after Goeckerman therapy
skos:notation
RIV/00179906:_____/12:10125393!RIV13-MZ0-00179906
n11:predkladatel
n18:ico%3A00179906
n3:aktivita
n4:I n4:Z
n3:aktivity
I, Z(MSM0021620812)
n3:cisloPeriodika
2
n3:dodaniDat
n13:2013
n3:domaciTvurceVysledku
n9:5861411 n9:8222525 n9:8520372 n9:7584881 n9:3377253
n3:druhVysledku
n5:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
154961
n3:idVysledku
RIV/00179906:_____/12:10125393
n3:jazykVysledku
n7:eng
n3:klicovaSlova
Goeckerman therapy; psoriasis; regulatory T cells
n3:klicoveSlovo
n14:regulatory%20T%20cells n14:psoriasis n14:Goeckerman%20therapy
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[B33BD5886A8B]
n3:nazevZdroje
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Kralove
n3:obor
n8:FN
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n13:2012
n3:svazekPeriodika
55
n3:tvurceVysledku
Borská, Lenka Krejsek, Jan Vokurková, Doris Kondělková, Kateřina Hamáková, Květoslava Andrýs, Ctirad Fiala, Zdeněk
n3:zamer
n15:MSM0021620812
s:issn
1211-4286
s:numberOfPages
5