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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F12%3A10123852%21RIV13-MZ0-00179906
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
https://www.jstage.jst.go.jp/article/bpb/35/10/35_b12-00205/_pdf
dcterms:description
The study describes a model of early sepsis induced in Wistar rats by a bolus injection of bacterial lipopolysaccharide (LPS) combined with interleukin-2 (IL-2). Both the separate and combined effects of LPS+IL-2 and gentamicin (GE) on glomerular filtration rate (GFR), tubular function and plasma biochemical parameters were evaluated. The major characteristics of the model are as follows: systemic microvascular leakage, a drop in GFR with only partially preserved tubular compensatory mechanisms, unchanged renal morphology, histologically proven pulmonary injuries and splenic alterations - signs of activation. In the range of therapeutic steady-state concentrations maintained over 3 hours, GE does not reduce GFR either in nonseptic or LPS+IL-2-treated rats. This is in contrast to its marked decrease due to the effect of LPS+IL-2 alone. An enlarged distribution volume and half-life along with a drop in renal clearance of GE proportional to that of GFR are the remarkable changes of GE disposition in this model. Nonrenal routes which, for the most part, compensate the reduced renal CL of GE in septic animals deserve further study. The study describes a model of early sepsis induced in Wistar rats by a bolus injection of bacterial lipopolysaccharide (LPS) combined with interleukin-2 (IL-2). Both the separate and combined effects of LPS+IL-2 and gentamicin (GE) on glomerular filtration rate (GFR), tubular function and plasma biochemical parameters were evaluated. The major characteristics of the model are as follows: systemic microvascular leakage, a drop in GFR with only partially preserved tubular compensatory mechanisms, unchanged renal morphology, histologically proven pulmonary injuries and splenic alterations - signs of activation. In the range of therapeutic steady-state concentrations maintained over 3 hours, GE does not reduce GFR either in nonseptic or LPS+IL-2-treated rats. This is in contrast to its marked decrease due to the effect of LPS+IL-2 alone. An enlarged distribution volume and half-life along with a drop in renal clearance of GE proportional to that of GFR are the remarkable changes of GE disposition in this model. Nonrenal routes which, for the most part, compensate the reduced renal CL of GE in septic animals deserve further study.
dcterms:title
A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2 A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2
skos:prefLabel
A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2 A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2
skos:notation
RIV/00179906:_____/12:10123852!RIV13-MZ0-00179906
n6:predkladatel
n17:ico%3A00179906
n3:aktivita
n8:I n8:S
n3:aktivity
I, S
n3:cisloPeriodika
10
n3:dodaniDat
n11:2013
n3:domaciTvurceVysledku
n14:2059320
n3:druhVysledku
n13:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
120546
n3:idVysledku
RIV/00179906:_____/12:10123852
n3:jazykVysledku
n12:eng
n3:klicovaSlova
multi-organ injury; early endotoxemia; LPSIL-2; pharmacokinetics; sepsis; gentamicin
n3:klicoveSlovo
n4:gentamicin n4:pharmacokinetics n4:early%20endotoxemia n4:sepsis n4:multi-organ%20injury n4:LPSIL-2
n3:kodStatuVydavatele
JP - Japonsko
n3:kontrolniKodProRIV
[58EE21FE6F85]
n3:nazevZdroje
Biological and Pharmaceutical Bulletin
n3:obor
n15:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n11:2012
n3:svazekPeriodika
35
n3:tvurceVysledku
Studená, Šárka Krs, Otakar Springer, Drahomíra Chládek, Jaroslav Slížová, Dáša Martínková, Jiřina Šenkeřík, Marian
n3:wos
000309332600015
s:issn
0918-6158
s:numberOfPages
8
n10:doi
10.1248/bpb.b12-00205