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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F12%3A10123248%21RIV13-MZ0-00179906
rdf:type
skos:Concept n7:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1111/j.1540-8191.2011.01399.x
dcterms:description
Background and aim: Isolated thoracic aortitis (ITA) is a newly-defined pathological entity with a still-unknown etiopathology and with some potential relationship to IgG4-related systemic disease. We investigated patients on whom the ascending aorta was operated to identify the clinical and histopathological features of ITA and its relationship to IgG4-related systemic disease. Methods: Two hundred fifty-one patients underwent replacement of the ascending aorta. Retrospective review of all histological reports was done to identify noninfectious aortitis. Immunohistochemical analysis of resected specimens was performed in all cases. Results: We found 11 (4.4%) patients with noninfectious aortitis aged 52 to 79 years; nine of the patients were female. All patients underwent ascending aorta replacement. The 30-day mortality was 0. During the follow-up period (median 12 months) four patients died (two of them because of progression of aortic disease). None of the seven living patients developed any IgG4-related diseases, and all had normal serum levels of IgG and IgG4. Conclusions: Surgical treatment of ITA has acceptable short- and mid-term results. Because follow-up serum levels of IgG and IgG4 were normal in survivors, postoperative corticosteroid therapy may not be indicated in patients in the absence of active vasculitis. Background and aim: Isolated thoracic aortitis (ITA) is a newly-defined pathological entity with a still-unknown etiopathology and with some potential relationship to IgG4-related systemic disease. We investigated patients on whom the ascending aorta was operated to identify the clinical and histopathological features of ITA and its relationship to IgG4-related systemic disease. Methods: Two hundred fifty-one patients underwent replacement of the ascending aorta. Retrospective review of all histological reports was done to identify noninfectious aortitis. Immunohistochemical analysis of resected specimens was performed in all cases. Results: We found 11 (4.4%) patients with noninfectious aortitis aged 52 to 79 years; nine of the patients were female. All patients underwent ascending aorta replacement. The 30-day mortality was 0. During the follow-up period (median 12 months) four patients died (two of them because of progression of aortic disease). None of the seven living patients developed any IgG4-related diseases, and all had normal serum levels of IgG and IgG4. Conclusions: Surgical treatment of ITA has acceptable short- and mid-term results. Because follow-up serum levels of IgG and IgG4 were normal in survivors, postoperative corticosteroid therapy may not be indicated in patients in the absence of active vasculitis.
dcterms:title
Repair of Thoracic Aortic Aneurysm Due to Noninfectious Aortitis Repair of Thoracic Aortic Aneurysm Due to Noninfectious Aortitis
skos:prefLabel
Repair of Thoracic Aortic Aneurysm Due to Noninfectious Aortitis Repair of Thoracic Aortic Aneurysm Due to Noninfectious Aortitis
skos:notation
RIV/00179906:_____/12:10123248!RIV13-MZ0-00179906
n7:predkladatel
n8:ico%3A00179906
n3:aktivita
n15:I
n3:aktivity
I
n3:cisloPeriodika
2
n3:dodaniDat
n9:2013
n3:domaciTvurceVysledku
n5:6953891 n5:7813813 n5:9951598 n5:3643034 n5:2536846 n5:4858077 n5:7025041
n3:druhVysledku
n16:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
165026
n3:idVysledku
RIV/00179906:_____/12:10123248
n3:jazykVysledku
n17:eng
n3:klicovaSlova
periaortitis; systemic-disease; lymphoplasmacytic aortitis; surgical pathology; ascending aortitis; IgG4-related sclerosing disease
n3:klicoveSlovo
n4:ascending%20aortitis n4:lymphoplasmacytic%20aortitis n4:systemic-disease n4:periaortitis n4:IgG4-related%20sclerosing%20disease n4:surgical%20pathology
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[FD7EC5987786]
n3:nazevZdroje
Journal of Cardiac Surgery
n3:obor
n14:FA
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n9:2012
n3:svazekPeriodika
27
n3:tvurceVysledku
Dominik, Jan Holubec, Tomáš Harrer, Jan Laco, Jan Vojáček, Jan Holubcová, Zdeňka Šteiner, Ivo
n3:wos
000302172800015
s:issn
0886-0440
s:numberOfPages
6
n12:doi
10.1111/j.1540-8191.2011.01399.x