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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F11%3A10108580%21RIV12-MZ0-00179906
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://86.120.250.122:8082/2011/numarul1/fulltext/The%20Effect%20of%20Oral%20Sodium%20Loading%20and%20Saline%20Infusion%20on%20Direct%20Active%20Renin%20in%20Healthy%20Volunteers.pdf
dcterms:description
In patients with suspected primary aldosteronism (PA), the aldosteroneto-renin ratio (ARR) is the most frequently recommended screening test. Further evaluation is based on hormonal changes during volume expansion. Both analyses are critically dependent on an accurate estimation of renin concentration. Direct active renin (DAR) is a novel laboratory technique used for plasma renin assessment. The objective of this study was to evaluate DAR for use in PA diagnostic work-ups. The study enrolled 69 healthy volunteers. Blood sampling was conducted before and after an increase in oral salt intake. Furthermore, a subset of 32 individuals uderwent a saline infusion suppression terst. DAR and serum aldosterone were measured in all blood samples. To calculate the ARR, serum aldosterone and DAR were expressed in ng/L. ARR values (median (range); 97,5 percentile) associated with normal and elevated oral salt intake were 8.4 (0.6-37.7); 26.3, and 6.8 (1.1-37.7); 19.6, respectively. DAR and serum aldosterone concentrations (median (range); 97.5 percentile) after saline infusion suppression were 2.9 (2.7-10.7); 7.2 ng/L and 30 (30-72); 54 pmol/L, respectively. The observed values may be useful in excluding a diagnosis of PA. In patients with suspected primary aldosteronism (PA), the aldosteroneto-renin ratio (ARR) is the most frequently recommended screening test. Further evaluation is based on hormonal changes during volume expansion. Both analyses are critically dependent on an accurate estimation of renin concentration. Direct active renin (DAR) is a novel laboratory technique used for plasma renin assessment. The objective of this study was to evaluate DAR for use in PA diagnostic work-ups. The study enrolled 69 healthy volunteers. Blood sampling was conducted before and after an increase in oral salt intake. Furthermore, a subset of 32 individuals uderwent a saline infusion suppression terst. DAR and serum aldosterone were measured in all blood samples. To calculate the ARR, serum aldosterone and DAR were expressed in ng/L. ARR values (median (range); 97,5 percentile) associated with normal and elevated oral salt intake were 8.4 (0.6-37.7); 26.3, and 6.8 (1.1-37.7); 19.6, respectively. DAR and serum aldosterone concentrations (median (range); 97.5 percentile) after saline infusion suppression were 2.9 (2.7-10.7); 7.2 ng/L and 30 (30-72); 54 pmol/L, respectively. The observed values may be useful in excluding a diagnosis of PA.
dcterms:title
The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers
skos:prefLabel
The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers
skos:notation
RIV/00179906:_____/11:10108580!RIV12-MZ0-00179906
n9:predkladatel
n10:ico%3A00179906
n3:aktivita
n20:Z
n3:aktivity
Z(MSM0021620817), Z(MZ0FNHK2005)
n3:cisloPeriodika
1
n3:dodaniDat
n17:2012
n3:domaciTvurceVysledku
n8:8737452 n8:7414854 n8:3677958 n8:6971849
n3:druhVysledku
n15:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
196384
n3:idVysledku
RIV/00179906:_____/11:10108580
n3:jazykVysledku
n4:eng
n3:klicovaSlova
direct active renin; primary aldosteronism
n3:klicoveSlovo
n11:primary%20aldosteronism n11:direct%20active%20renin
n3:kodStatuVydavatele
RO - Rumunsko
n3:kontrolniKodProRIV
[AB1E1403BC86]
n3:nazevZdroje
Acta Endocrinology
n3:obor
n5:FA
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n17:2011
n3:svazekPeriodika
7
n3:tvurceVysledku
Ceral, Jiří Pelouch, Radek Malířová, Eva Solař, Miroslav Kopecká, P.
n3:wos
000289007600004
n3:zamer
n6:MZ0FNHK2005 n6:MSM0021620817
s:issn
1841-0987
s:numberOfPages
6
n14:doi
10.4183/aeb.2011.33