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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F11%3A10107274%21RIV12-MZ0-00179906
rdf:type
n14:Vysledek skos:Concept
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022806/pdf/1471-244X-11-2.pdf
dcterms:description
BACKGROUND: Antipsychotic treatment has been repeatedly found to be associated with an increased risk for venous thromboembolism in schizophrenia. The extent to which the propensity for venous thromboembolism is linked to antipsychotic medication alone or psychosis itself is unclear. The objective of this study was to determine whether markers of thrombogenesis are increased in psychotic patients who have not yet been treated with antipsychotic medication. METHODS: We investigated the plasma levels of markers indicating activation of coagulation (D-dimers and Factor VIII) and platelets (soluble P-selectin, sP-selectin) in an antipsychotic-naive group of fourteen men and eleven women with acute psychosis (age 29.1 +- 8.3 years, body mass index 23.6 +- 4.7), and twenty-five healthy volunteers were matched for age, gender and body mass index. RESULTS: D-dimers (median 0.38 versus 0.19 mg/l, mean 1.12 +- 2.38 versus 0.28 +- 0.3 mg/l; P = 0.003) and sP-selectin (median 204.1 versus 112.4 ng/ml, mean 209.9 +- 124 versus 124.1 +- 32; P = 0.0005) plasma levels were significantly increased in the group of patients with acute psychosis as compared with healthy volunteers. We found a trend (median 148% versus 110%, mean 160 +- 72.5 versus 123 +- 62.5; P = 0.062) of increased plasma levels of factor VIII in psychotic patients as compared with healthy volunteers. CONCLUSIONS: The results suggest that at least a part of venous thromboembolic events in patients with acute psychosis may be induced by pathogenic mechanisms related to psychosis rather than by antipsychotic treatment. Finding an exact cause for venous thromboembolism in psychotic patients is necessary for its effective treatment and prevention. BACKGROUND: Antipsychotic treatment has been repeatedly found to be associated with an increased risk for venous thromboembolism in schizophrenia. The extent to which the propensity for venous thromboembolism is linked to antipsychotic medication alone or psychosis itself is unclear. The objective of this study was to determine whether markers of thrombogenesis are increased in psychotic patients who have not yet been treated with antipsychotic medication. METHODS: We investigated the plasma levels of markers indicating activation of coagulation (D-dimers and Factor VIII) and platelets (soluble P-selectin, sP-selectin) in an antipsychotic-naive group of fourteen men and eleven women with acute psychosis (age 29.1 +- 8.3 years, body mass index 23.6 +- 4.7), and twenty-five healthy volunteers were matched for age, gender and body mass index. RESULTS: D-dimers (median 0.38 versus 0.19 mg/l, mean 1.12 +- 2.38 versus 0.28 +- 0.3 mg/l; P = 0.003) and sP-selectin (median 204.1 versus 112.4 ng/ml, mean 209.9 +- 124 versus 124.1 +- 32; P = 0.0005) plasma levels were significantly increased in the group of patients with acute psychosis as compared with healthy volunteers. We found a trend (median 148% versus 110%, mean 160 +- 72.5 versus 123 +- 62.5; P = 0.062) of increased plasma levels of factor VIII in psychotic patients as compared with healthy volunteers. CONCLUSIONS: The results suggest that at least a part of venous thromboembolic events in patients with acute psychosis may be induced by pathogenic mechanisms related to psychosis rather than by antipsychotic treatment. Finding an exact cause for venous thromboembolism in psychotic patients is necessary for its effective treatment and prevention.
dcterms:title
Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study
skos:prefLabel
Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study
skos:notation
RIV/00179906:_____/11:10107274!RIV12-MZ0-00179906
n14:predkladatel
n19:ico%3A00179906
n3:aktivita
n11:Z
n3:aktivity
Z(MSM0021620816), Z(MZ0FNHK2005)
n3:cisloPeriodika
January
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
n13:5023408 n13:6682391 n13:8888515 n13:8573409 n13:7125364 n13:7584881
n3:druhVysledku
n20:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
210687
n3:idVysledku
RIV/00179906:_____/11:10107274
n3:jazykVysledku
n17:eng
n3:klicovaSlova
markers of thrombogenesis; schizophrenia; psychosis; thromboembolism
n3:klicoveSlovo
n7:thromboembolism n7:psychosis n7:markers%20of%20thrombogenesis n7:schizophrenia
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[59B8380D4B13]
n3:nazevZdroje
BMC Psychiatry
n3:obor
n5:FL
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
11
n3:tvurceVysledku
Masopust, Jiří Malý, Radovan Bažant, Jan Hosák, Ladislav Andrýs, Ctirad Vališ, Martin
n3:wos
000286219400001
n3:zamer
n6:MSM0021620816 n6:MZ0FNHK2005
s:issn
1471-244X
s:numberOfPages
5
n18:doi
10.1186/1471-244X-11-2