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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F11%3A10105104%21RIV12-MZ0-00179906
rdf:type
n3:Vysledek skos:Concept
dcterms:description
The objectives of this review are to describe neurogenesis in the adult murine and human brain (with particular emphasis to morphological aspects of this process) and to determine to what extent it is affected in animal models of HD and in the human HD brain. Due to very limited evidence referring to the impact of striatal pathology of HD phenotype on the adult neurogenesis in the SEZ, some results gained from our studies on two rat models of HD, i.e. the neurotoxic lesion and transgenic HD rats, and on human HD brains are discussed. The objectives of this review are to describe neurogenesis in the adult murine and human brain (with particular emphasis to morphological aspects of this process) and to determine to what extent it is affected in animal models of HD and in the human HD brain. Due to very limited evidence referring to the impact of striatal pathology of HD phenotype on the adult neurogenesis in the SEZ, some results gained from our studies on two rat models of HD, i.e. the neurotoxic lesion and transgenic HD rats, and on human HD brains are discussed.
dcterms:title
Intervention of Proliferation and Differentiation of Endogenous Neural Stem Cells in the Neurodegenerative Process of Huntington's Disease Phenotype Intervention of Proliferation and Differentiation of Endogenous Neural Stem Cells in the Neurodegenerative Process of Huntington's Disease Phenotype
skos:prefLabel
Intervention of Proliferation and Differentiation of Endogenous Neural Stem Cells in the Neurodegenerative Process of Huntington's Disease Phenotype Intervention of Proliferation and Differentiation of Endogenous Neural Stem Cells in the Neurodegenerative Process of Huntington's Disease Phenotype
skos:notation
RIV/00179906:_____/11:10105104!RIV12-MZ0-00179906
n3:predkladatel
n13:ico%3A00179906
n4:aktivita
n6:Z n6:I
n4:aktivity
I, Z(MSM0021620820)
n4:cisloPeriodika
4
n4:dodaniDat
n18:2012
n4:domaciTvurceVysledku
n17:2771497
n4:druhVysledku
n9:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
205538
n4:idVysledku
RIV/00179906:_____/11:10105104
n4:jazykVysledku
n16:eng
n4:klicovaSlova
Histopathology; Transgenic HD rats; Neurotoxin-induced model; Huntington's disease; Subependymal zone; Neural stem cells; Adult neurogenesis
n4:klicoveSlovo
n7:Transgenic%20HD%20rats n7:Adult%20neurogenesis n7:Subependymal%20zone n7:Huntington%27s%20disease n7:Histopathology n7:Neural%20stem%20cells n7:Neurotoxin-induced%20model
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[F5E39D30400B]
n4:nazevZdroje
CNS and Neurological Disorders - Drug Targets
n4:obor
n11:EA
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n18:2011
n4:svazekPeriodika
10
n4:tvurceVysledku
Rudolf, Emil Gunčová, Ivana Látr, Ivan Mazurová, Yvona
n4:wos
000291634700008
n4:zamer
n10:MSM0021620820
s:issn
1871-5273
s:numberOfPages
14