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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F11%3A10099227%21RIV13-MZ0-00179906
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/med.20192/pdf
dcterms:description
During the last two decades, the treatment of OPP exposure has become more widely discussed because of growing agricultural production, industrialisation and harmful social issues (e.g. suicides). In this review is summarised the design, evaluation and structure-activity relationship studies of recently produced AChE reactivators. Since pralidoxime, over 300 oximes have been produced or tested against OPP poisoning, and several novel compounds show very promising abilities as comparable (or higher) to commercial oximes. Some of these are highlighted for their further testing of OPP exposure, and additionally, the main structure-activity relationship of AChE reactivators against OPP are discussed. During the last two decades, the treatment of OPP exposure has become more widely discussed because of growing agricultural production, industrialisation and harmful social issues (e.g. suicides). In this review is summarised the design, evaluation and structure-activity relationship studies of recently produced AChE reactivators. Since pralidoxime, over 300 oximes have been produced or tested against OPP poisoning, and several novel compounds show very promising abilities as comparable (or higher) to commercial oximes. Some of these are highlighted for their further testing of OPP exposure, and additionally, the main structure-activity relationship of AChE reactivators against OPP are discussed.
dcterms:title
Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides
skos:prefLabel
Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides
skos:notation
RIV/00179906:_____/11:10099227!RIV13-MZ0-00179906
n9:predkladatel
n10:ico%3A00179906
n4:aktivita
n20:P n20:I
n4:aktivity
I, P(ME09086)
n4:cisloPeriodika
4
n4:dodaniDat
n12:2013
n4:domaciTvurceVysledku
n17:6469922
n4:druhVysledku
n18:J
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
193530
n4:idVysledku
RIV/00179906:_____/11:10099227
n4:jazykVysledku
n16:eng
n4:klicovaSlova
SAR; oxime; reactivation; insecticide; pesticide; acetylcholinesterase
n4:klicoveSlovo
n5:acetylcholinesterase n5:pesticide n5:reactivation n5:oxime n5:SAR n5:insecticide
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[FBE1A09EAE2F]
n4:nazevZdroje
Medicinal Research Reviews
n4:obor
n15:FR
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:projekt
n13:ME09086
n4:rokUplatneniVysledku
n12:2011
n4:svazekPeriodika
31
n4:tvurceVysledku
Doležal, Martin Musílek, Kamil Gunn-Moore, Frank Kuča, Kamil
n4:wos
000292570100003
s:issn
0198-6325
s:numberOfPages
28
n19:doi
10.1002/med.20192