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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F11%3A10081782%21RIV12-MZ0-00179906
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://www.nature.com/hr/journal/v34/n1/full/hr2010183a.html
dcterms:description
Difficult-to-control arterial hypertension is a common medical problem that may result from severe hypertensive disease or from poor adherence to the recommended medical treatment. The use of serum levels of prescribed antihypertensive drugs to evaluate the adherence in individuals with difficult-to-control arterial hypertension was descibed. Serum drug levels (SDLs) were evaluated by liquid chromatography with mass spectrometry. Eighty-four patients who presented with uncontrolled blood pressure despite the recommended combination of at least three antihypertensives were enrolled in the study. In 55 (65.5%) patients, non-adherence was diagnosed. Our data suggest that an assessment of SDLs might be helpful before an extensive evaluation is initiated for difficult-to-control hypertension. Difficult-to-control arterial hypertension is a common medical problem that may result from severe hypertensive disease or from poor adherence to the recommended medical treatment. The use of serum levels of prescribed antihypertensive drugs to evaluate the adherence in individuals with difficult-to-control arterial hypertension was descibed. Serum drug levels (SDLs) were evaluated by liquid chromatography with mass spectrometry. Eighty-four patients who presented with uncontrolled blood pressure despite the recommended combination of at least three antihypertensives were enrolled in the study. In 55 (65.5%) patients, non-adherence was diagnosed. Our data suggest that an assessment of SDLs might be helpful before an extensive evaluation is initiated for difficult-to-control hypertension.
dcterms:title
Difficult-to-control arterial hypertension or uncooperative patients? The assessment of serum antihypertensive drug levels to differentiate non-responsiveness from non-adherence to recommended therapy Difficult-to-control arterial hypertension or uncooperative patients? The assessment of serum antihypertensive drug levels to differentiate non-responsiveness from non-adherence to recommended therapy
skos:prefLabel
Difficult-to-control arterial hypertension or uncooperative patients? The assessment of serum antihypertensive drug levels to differentiate non-responsiveness from non-adherence to recommended therapy Difficult-to-control arterial hypertension or uncooperative patients? The assessment of serum antihypertensive drug levels to differentiate non-responsiveness from non-adherence to recommended therapy
skos:notation
RIV/00179906:_____/11:10081782!RIV12-MZ0-00179906
n10:predkladatel
n11:ico%3A00179906
n5:aktivita
n6:Z
n5:aktivity
Z(MSM0021620817), Z(MZ0FNHK2005)
n5:cisloPeriodika
1
n5:dodaniDat
n15:2012
n5:domaciTvurceVysledku
n7:3117669 n7:7414854 n7:6971849 n7:2448270 n7:3677958
n5:druhVysledku
n19:J
n5:duvernostUdaju
n8:S
n5:entitaPredkladatele
n16:predkladatel
n5:idSjednocenehoVysledku
194601
n5:idVysledku
RIV/00179906:_____/11:10081782
n5:jazykVysledku
n18:eng
n5:klicovaSlova
mass spectrometry; chromatography liquid; medication adherence; antihypertensive agents; drug therapy; hypertension
n5:klicoveSlovo
n12:medication%20adherence n12:antihypertensive%20agents n12:hypertension n12:mass%20spectrometry n12:drug%20therapy n12:chromatography%20liquid
n5:kodStatuVydavatele
JP - Japonsko
n5:kontrolniKodProRIV
[5AAC8972DE76]
n5:nazevZdroje
Hypertension Research
n5:obor
n13:FA
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
6
n5:rokUplatneniVysledku
n15:2011
n5:svazekPeriodika
34
n5:tvurceVysledku
Solař, Miroslav Voříšek, Viktor Bíma, Marcel Ceral, Jiří Pelouch, Radek Habrdová, Vilma
n5:wos
000285919100018
n5:zamer
n9:MSM0021620817 n9:MZ0FNHK2005
s:issn
0916-9636
s:numberOfPages
4
n3:doi
10.1038/hr.2010.183