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Statements

Subject Item
n2:RIV%2F00179906%3A_____%2F06%3A00000079%21RIV07-MZ0-00179906
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Některé měřitelné rysy lidské osobnosti predisponují k rozvoji určité psychopatologie. Zvýšená potřeba vyhledávat nové podněty (novelty seeking, NS) hraje významnou roli v etiopatogenezi závislosti na návykových látkách. Povahový rys NS má vztah k dopaminergní neurotransmisi. Catechol-O-methyltransferáza (COMT) je nezbytná při odbourávání dopaminu. Cílem naší práce bylo zjistit, zda funkční polymorfismus Val158Met genu pro COMT má vztah ke skóru NS u osob, závislých na pervitinu. Measurable traits of human personality may mark the predispostion to psychopathology. Increase novelty seeking plays an important role in the pathogenesis of substance abuse. Novelty seeking, one of the fundamental traits of the human temperament, is relate to dopamine. Catechol-O-methyltransferase (COMT) is essential for dopamine inactivation. The aim of our study was to assess whether the COMT gene Val158Met functional polymorphism in patients dependent on methamphetamine is related to their novelty siiking score. Measurable traits of human personality may mark the predispostion to psychopathology. Increase novelty seeking plays an important role in the pathogenesis of substance abuse. Novelty seeking, one of the fundamental traits of the human temperament, is relate to dopamine. Catechol-O-methyltransferase (COMT) is essential for dopamine inactivation. The aim of our study was to assess whether the COMT gene Val158Met functional polymorphism in patients dependent on methamphetamine is related to their novelty siiking score.
dcterms:title
The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results Polymorfismus Val158Met genu pro COMT a novelty seeking u závislosti na pervitinu The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results
skos:prefLabel
The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results Polymorfismus Val158Met genu pro COMT a novelty seeking u závislosti na pervitinu
skos:notation
RIV/00179906:_____/06:00000079!RIV07-MZ0-00179906
n5:strany
799;802
n5:aktivita
n12:Z
n5:aktivity
Z(MZ0FNHK2005)
n5:cisloPeriodika
6
n5:dodaniDat
n10:2007
n5:domaciTvurceVysledku
n9:2617536 n9:2402777 n9:8573409 n9:3791793
n5:druhVysledku
n13:J
n5:duvernostUdaju
n11:S
n5:entitaPredkladatele
n6:predkladatel
n5:idSjednocenehoVysledku
469532
n5:idVysledku
RIV/00179906:_____/06:00000079
n5:jazykVysledku
n17:eng
n5:klicovaSlova
methamphetamine dependence; novelty-seeking behavior; COMT; COMT Gene Val158Met polymorphism; dopamine
n5:klicoveSlovo
n8:COMT n8:COMT%20Gene%20Val158Met%20polymorphism n8:dopamine n8:methamphetamine%20dependence n8:novelty-seeking%20behavior
n5:kodStatuVydavatele
SE - Švédské království
n5:kontrolniKodProRIV
[7B650B5359CA]
n5:nazevZdroje
Neuroendocrinology Letters
n5:obor
n14:FL
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
5
n5:rokUplatneniVysledku
n10:2006
n5:svazekPeriodika
27
n5:tvurceVysledku
Beránek, Martin Hosák, Ladislav Libiger, Jan Čížek, Jiří
n5:zamer
n15:MZ0FNHK2005
s:issn
0172-780X
s:numberOfPages
4