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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F15%3A00061246%21RIV15-MSM-00159816
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Left ventricular systolic elastance (Ees) and diastolic elastance (Eed) correlate with arterial elastance (Ea), but it is unknown how chronic changes in arterial compliance and resistance, which determine Ea, might differentially affect cardiac properties with ageing. We sought to characterize chronic changes in pulsatile and resistive arterial load and correlate them with longitudinal changes in LV structure and function in a prospective, community-based study. METHODS AND RESULTS: Comprehensive echocardiography was performed in 722 subjects participating in a randomly selected community-based study at two examinations separated by 4 years, allowing for assessment of LV Ees, Eed, and end-diastolic volume (EDV), Ea, total arterial compliance, and systemic vascular resistance at both examinations. Chronic changes in resistance and heart rate were the dominant contributors to change in Ea. Changes in arterial compliance had little impact on changes in Ea, but were strongly associated with changes in Ees. The combination of increased resistance and decreased compliance was associated with the largest increase in LV diastolic stiffness, an effect that was mediated by a decrease in LVEDV. In contrast, subjects with both improved arterial compliance and decreased resistance displayed an increase in LVEDV over time, with no increase in LV Eed. CONCLUSION: Increases in pulsatile arterial load with ageing contribute more to LV systolic stiffening, while combined pulsatile and resistive loading changes are associated with positive and negative chamber remodelling and diastolic stiffness. Therapies designed to improve arterial resistance and particularly to enhance aortic compliance may hold promise to prevent or reverse cardiac ageing and its sequelae. Left ventricular systolic elastance (Ees) and diastolic elastance (Eed) correlate with arterial elastance (Ea), but it is unknown how chronic changes in arterial compliance and resistance, which determine Ea, might differentially affect cardiac properties with ageing. We sought to characterize chronic changes in pulsatile and resistive arterial load and correlate them with longitudinal changes in LV structure and function in a prospective, community-based study. METHODS AND RESULTS: Comprehensive echocardiography was performed in 722 subjects participating in a randomly selected community-based study at two examinations separated by 4 years, allowing for assessment of LV Ees, Eed, and end-diastolic volume (EDV), Ea, total arterial compliance, and systemic vascular resistance at both examinations. Chronic changes in resistance and heart rate were the dominant contributors to change in Ea. Changes in arterial compliance had little impact on changes in Ea, but were strongly associated with changes in Ees. The combination of increased resistance and decreased compliance was associated with the largest increase in LV diastolic stiffness, an effect that was mediated by a decrease in LVEDV. In contrast, subjects with both improved arterial compliance and decreased resistance displayed an increase in LVEDV over time, with no increase in LV Eed. CONCLUSION: Increases in pulsatile arterial load with ageing contribute more to LV systolic stiffening, while combined pulsatile and resistive loading changes are associated with positive and negative chamber remodelling and diastolic stiffness. Therapies designed to improve arterial resistance and particularly to enhance aortic compliance may hold promise to prevent or reverse cardiac ageing and its sequelae.
dcterms:title
Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans
skos:prefLabel
Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans
skos:notation
RIV/00159816:_____/15:00061246!RIV15-MSM-00159816
n3:aktivita
n12:P
n3:aktivity
P(ED1.100/02/0123)
n3:cisloPeriodika
1
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n10:6953069
n3:druhVysledku
n13:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
197
n3:idVysledku
RIV/00159816:_____/15:00061246
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Left ventricular stiffness; Heart failure with preserved ejection fraction; Heart failure; Arterial resistance; Arterial compliance; Ageing
n3:klicoveSlovo
n5:Left%20ventricular%20stiffness n5:Arterial%20compliance n5:Arterial%20resistance n5:Heart%20failure n5:Heart%20failure%20with%20preserved%20ejection%20fraction n5:Ageing
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E6D51E114B33]
n3:nazevZdroje
European Journal of Heart Failure
n3:obor
n15:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n11:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n7:2015
n3:svazekPeriodika
17
n3:tvurceVysledku
Redfield, M.M Wohlfahrt, Peter Lopez-Jimenez, F. Borlaug, B. A. Rodeheffer, R. J. Melenovsky, V.
n3:wos
000348058300005
s:issn
1388-9842
s:numberOfPages
8
n9:doi
10.1002/ejhf.190