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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F15%3A00061096%21RIV15-MSM-00159816
rdf:type
skos:Concept n16:Vysledek
dcterms:description
It has recently been proposed that heart failure is a risk factor for Alzheimer's disease. Decreased cerebral blood flow and neurohormonal activation due to heart failure may contribute to the dysfunction of the neurovascular unit and cause an energy crisis in neurons. This leads to the impaired clearance of amyloid beta and hyperphosphorylation of tau protein, resulting in the formation of amyloid beta plaques and neurofibrillary tangles. In this article, we will summarize the current understanding of the relationship between heart failure and Alzheimer's disease based on epidemiological studies, brain imaging research, pathological findings and the use of animal models. The importance of atherosclerosis, myocardial infarction, atrial fibrillation, blood pressure and valve disease as well as the effect of relevant medications will be discussed. It has recently been proposed that heart failure is a risk factor for Alzheimer's disease. Decreased cerebral blood flow and neurohormonal activation due to heart failure may contribute to the dysfunction of the neurovascular unit and cause an energy crisis in neurons. This leads to the impaired clearance of amyloid beta and hyperphosphorylation of tau protein, resulting in the formation of amyloid beta plaques and neurofibrillary tangles. In this article, we will summarize the current understanding of the relationship between heart failure and Alzheimer's disease based on epidemiological studies, brain imaging research, pathological findings and the use of animal models. The importance of atherosclerosis, myocardial infarction, atrial fibrillation, blood pressure and valve disease as well as the effect of relevant medications will be discussed.
dcterms:title
Heart failure and Alzheimer's disease Heart failure and Alzheimer's disease
skos:prefLabel
Heart failure and Alzheimer's disease Heart failure and Alzheimer's disease
skos:notation
RIV/00159816:_____/15:00061096!RIV15-MSM-00159816
n3:aktivita
n13:P
n3:aktivity
P(ED1.100/02/0123)
n3:cisloPeriodika
4
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n10:1011820
n3:druhVysledku
n15:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
174
n3:idVysledku
RIV/00159816:_____/15:00061096
n3:jazykVysledku
n17:eng
n3:klicovaSlova
neurovascular unit; neurocardiology; heart failure; dementia; Alzheimer´s disease
n3:klicoveSlovo
n4:neurocardiology n4:dementia n4:heart%20failure n4:Alzheimer%C2%B4s%20disease n4:neurovascular%20unit
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[AC75FE187B3C]
n3:nazevZdroje
Journal of Internal Medicine
n3:obor
n11:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n12:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n7:2015
n3:svazekPeriodika
277
n3:tvurceVysledku
Winblad, B. Religa, P. Lund, L.H Religa, D. Eriksdotter, M. Čermáková, Pavla
n3:wos
000351692100003
s:issn
0954-6820
s:numberOfPages
20
n18:doi
10.1111/joim.12287