This HTML5 document contains 43 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n12http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n5http://linked.opendata.cz/resource/domain/vavai/projekt/
n14http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
n7http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00159816%3A_____%2F14%3A00061218%21RIV15-MSM-00159816/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n9http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n8http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F14%3A00061218%21RIV15-MSM-00159816
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The generation of haematopoietic progenitors from human pluripotent stem cells (hPSCs) presents great promise for cell-replacement therapies. However, current protocols for haematopoietic differentiation of hPSCs suffer from low efficiency and functional defects in the derived cells. The technology is also limited by variable ability of hPSC lines to generate blood cells in vitro. To address this issue, methodologies for haematopoietic differentiation in feeder-free conditions were applied to available human embryonic stem cell (hESC) and human induced pluripotent stem cell (hiPSC) lines in this study. It was found that these cell lines did not generate haematopoietic progenitors to such an extent as did H1 and H9 hESC lines that were used for this purpose in the vast majority of relevant studies. These results suggest that for clinical application of blood cells derived from hPSCs, possibly from autologous hiPSCs, it is necessary to overcome the variability in the haematopoietic developmental potential of individual hPSC lines. The generation of haematopoietic progenitors from human pluripotent stem cells (hPSCs) presents great promise for cell-replacement therapies. However, current protocols for haematopoietic differentiation of hPSCs suffer from low efficiency and functional defects in the derived cells. The technology is also limited by variable ability of hPSC lines to generate blood cells in vitro. To address this issue, methodologies for haematopoietic differentiation in feeder-free conditions were applied to available human embryonic stem cell (hESC) and human induced pluripotent stem cell (hiPSC) lines in this study. It was found that these cell lines did not generate haematopoietic progenitors to such an extent as did H1 and H9 hESC lines that were used for this purpose in the vast majority of relevant studies. These results suggest that for clinical application of blood cells derived from hPSCs, possibly from autologous hiPSCs, it is necessary to overcome the variability in the haematopoietic developmental potential of individual hPSC lines.
dcterms:title
Haematopoietic Developmental Potential of Human Pluripotent Stem Cell Lines Haematopoietic Developmental Potential of Human Pluripotent Stem Cell Lines
skos:prefLabel
Haematopoietic Developmental Potential of Human Pluripotent Stem Cell Lines Haematopoietic Developmental Potential of Human Pluripotent Stem Cell Lines
skos:notation
RIV/00159816:_____/14:00061218!RIV15-MSM-00159816
n4:aktivita
n13:P
n4:aktivity
P(ED1.100/02/0123), P(GBP302/12/G157)
n4:cisloPeriodika
S1
n4:dodaniDat
n8:2015
n4:domaciTvurceVysledku
n12:4748891 n12:8054142
n4:druhVysledku
n15:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
18721
n4:idVysledku
RIV/00159816:_____/14:00061218
n4:jazykVysledku
n16:eng
n4:klicovaSlova
CD34+ cells; embryoid bodies; haematopoietic development; human pluripotent stem cell
n4:klicoveSlovo
n9:haematopoietic%20development n9:embryoid%20bodies n9:human%20pluripotent%20stem%20cell n9:CD34%2B%20cells
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[3AA63847419D]
n4:nazevZdroje
Folia biologica (Praha)
n4:obor
n17:EB
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
4
n4:projekt
n5:ED1.100%2F02%2F0123 n5:GBP302%2F12%2FG157
n4:rokUplatneniVysledku
n8:2014
n4:svazekPeriodika
60
n4:tvurceVysledku
Šimara, Pavel Tesařová, L. Stejskal, S. Krontorád Koutná, Irena
n4:wos
000343275800015
s:issn
0015-5500
s:numberOfPages
5