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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F14%3A00061187%21RIV15-MSM-00159816
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Objective: The aim of the present systematic review and meta-analysis was to evaluate the safety and efficacy of intensive blood pressure (BP) reduction in patients with acute-onset intracerebral hemorrhage (ICH) using data from randomized controlled trials. Methods: We conducted a systematic review and meta-analysis according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines of all available randomized controlled trials that randomized patients with acute ICH to either intensive or guideline BP-reduction protocols. Results: We identified 4 eligible studies, including a total of 3,315 patients (mean age 63.4 6 1.4 years, 64% men). Death rates were similar between patients randomized to intensive BP-lowering treatment and those receiving guideline BP-lowering treatment (odds ratio 5 1.01, 95% confidence interval: 0.83-1.23; p 5 0.914). Intensive BP-lowering treatment tended to be associated with lower 3-month death or dependency (modified Rankin Scale grades 3-6) compared with guideline treatment (odds ratio 5 0.87, 95% confidence interval: 0.76-1.01; p 5 0.062). No evidence of heterogeneity between estimates (I2 5 0%; p 5 0.723), or publication bias in the funnel plots (p 5 0.993, Egger statistical test), was detected. Intensive BP reduction was also associated with a greater attenuation of absolute hematoma growth at 24 hours (standardized mean difference 6 SE: 20.110 6 0.053; p 5 0.038). Conclusions: Our findings indicate that intensive BP management in patients with acute ICH is safe. Fewer intensively treated patients had unfavorable 3-month functional outcome although this finding did not reach significance. Moreover, intensive BP reduction appears to be associated with a greater attenuation of absolute hematoma growth at 24 hours. Objective: The aim of the present systematic review and meta-analysis was to evaluate the safety and efficacy of intensive blood pressure (BP) reduction in patients with acute-onset intracerebral hemorrhage (ICH) using data from randomized controlled trials. Methods: We conducted a systematic review and meta-analysis according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines of all available randomized controlled trials that randomized patients with acute ICH to either intensive or guideline BP-reduction protocols. Results: We identified 4 eligible studies, including a total of 3,315 patients (mean age 63.4 6 1.4 years, 64% men). Death rates were similar between patients randomized to intensive BP-lowering treatment and those receiving guideline BP-lowering treatment (odds ratio 5 1.01, 95% confidence interval: 0.83-1.23; p 5 0.914). Intensive BP-lowering treatment tended to be associated with lower 3-month death or dependency (modified Rankin Scale grades 3-6) compared with guideline treatment (odds ratio 5 0.87, 95% confidence interval: 0.76-1.01; p 5 0.062). No evidence of heterogeneity between estimates (I2 5 0%; p 5 0.723), or publication bias in the funnel plots (p 5 0.993, Egger statistical test), was detected. Intensive BP reduction was also associated with a greater attenuation of absolute hematoma growth at 24 hours (standardized mean difference 6 SE: 20.110 6 0.053; p 5 0.038). Conclusions: Our findings indicate that intensive BP management in patients with acute ICH is safe. Fewer intensively treated patients had unfavorable 3-month functional outcome although this finding did not reach significance. Moreover, intensive BP reduction appears to be associated with a greater attenuation of absolute hematoma growth at 24 hours.
dcterms:title
Intensive blood pressure reduction in acute intracerebral hemorrhage: A meta-analysis Intensive blood pressure reduction in acute intracerebral hemorrhage: A meta-analysis
skos:prefLabel
Intensive blood pressure reduction in acute intracerebral hemorrhage: A meta-analysis Intensive blood pressure reduction in acute intracerebral hemorrhage: A meta-analysis
skos:notation
RIV/00159816:_____/14:00061187!RIV15-MSM-00159816
n3:aktivita
n16:P
n3:aktivity
P(ED1.100/02/0123)
n3:cisloPeriodika
17
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
Tsivgoulis, Georgios
n3:druhVysledku
n17:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
22249
n3:idVysledku
RIV/00159816:_____/14:00061187
n3:jazykVysledku
n8:eng
n3:klicovaSlova
intracerebral hemorrhage; blood pressure
n3:klicoveSlovo
n10:blood%20pressure n10:intracerebral%20hemorrhage
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[3B76156F98C1]
n3:nazevZdroje
Neurology
n3:obor
n9:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n14:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
83
n3:tvurceVysledku
Tsivgoulis, Georgios Triantafyllou, N. Katsanos, A. H. Rizos, I. Alexandrov, A. V. Boviatsis, E. Butcher, K. S.
n3:wos
000344851100010
s:issn
0028-3878
s:numberOfPages
7
n4:doi
10.1212/WNL.0000000000000917