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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F14%3A00061030%21RIV15-MSM-00159816
rdf:type
skos:Concept n12:Vysledek
dcterms:description
This review highlights the protective roles of bilirubin against the atherosclerotic process. Bilirubin belongs to the superfamily of tetrapyrrolic compounds formed during heme catabolism. Although for decades bilirubin was considered to be a harmful waste product, recent epidemiologic studies have shown that serum bilirubin levels have consistently been inversely associated with cardiovascular disease (CVD), as well as cardiovascular risk factors such as metabolic syndrome and diabetes. These clinical studies are supported by in vitro and in vivo experimental data and have demonstrated that bilirubin not only has an ability to scavenge overproduced reactive oxygen species and inhibit vascular smooth muscle cell proliferation but, additionally, has anti-inflammatory effects. In this review, we will discuss the inverse association of serum bilirubin and CVD and cardiovascular risk factors established in various clinical studies. We also review detailed experimental studies about the effect of bilirubin on atherosclerotic processes. In vitro, animal and human studies have proved that bilirubin inhibits oxidation of cholesterol which is an important step of atherosclerosis. Bilirubin attenuates chemotactic activity of monocytes and strongly inhibits adhesion of leukocytes to venule and production of pro-inflammatory cytokines. Bilirubin has inhibited serum-driven smooth muscle cell cycle progression at the G1 phase. Lastly, we will discuss briefly the influence of bilirubin on lipoprotein composition and endothelial dysfunction. This review highlights the protective roles of bilirubin against the atherosclerotic process. Bilirubin belongs to the superfamily of tetrapyrrolic compounds formed during heme catabolism. Although for decades bilirubin was considered to be a harmful waste product, recent epidemiologic studies have shown that serum bilirubin levels have consistently been inversely associated with cardiovascular disease (CVD), as well as cardiovascular risk factors such as metabolic syndrome and diabetes. These clinical studies are supported by in vitro and in vivo experimental data and have demonstrated that bilirubin not only has an ability to scavenge overproduced reactive oxygen species and inhibit vascular smooth muscle cell proliferation but, additionally, has anti-inflammatory effects. In this review, we will discuss the inverse association of serum bilirubin and CVD and cardiovascular risk factors established in various clinical studies. We also review detailed experimental studies about the effect of bilirubin on atherosclerotic processes. In vitro, animal and human studies have proved that bilirubin inhibits oxidation of cholesterol which is an important step of atherosclerosis. Bilirubin attenuates chemotactic activity of monocytes and strongly inhibits adhesion of leukocytes to venule and production of pro-inflammatory cytokines. Bilirubin has inhibited serum-driven smooth muscle cell cycle progression at the G1 phase. Lastly, we will discuss briefly the influence of bilirubin on lipoprotein composition and endothelial dysfunction.
dcterms:title
Effects of serum bilirubin on atherosclerotic processes Effects of serum bilirubin on atherosclerotic processes
skos:prefLabel
Effects of serum bilirubin on atherosclerotic processes Effects of serum bilirubin on atherosclerotic processes
skos:notation
RIV/00159816:_____/14:00061030!RIV15-MSM-00159816
n3:aktivita
n11:P
n3:aktivity
P(ED1.100/02/0123)
n3:cisloPeriodika
3
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n17:9514325
n3:druhVysledku
n10:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
13768
n3:idVysledku
RIV/00159816:_____/14:00061030
n3:jazykVysledku
n15:eng
n3:klicovaSlova
cardiovascular disease; bilirubin; Atherosclerosis
n3:klicoveSlovo
n13:bilirubin n13:cardiovascular%20disease n13:Atherosclerosis
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[5CF80044C35E]
n3:nazevZdroje
Annals of Medicine
n3:obor
n16:FE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:projekt
n18:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
46
n3:tvurceVysledku
Kružliak, Peter Kang, Seung Joo Lee, Changhyun
n3:wos
000335584000005
s:issn
0785-3890
s:numberOfPages
10
n6:doi
10.3109/07853890.2014.895588