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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F14%3A00060944%21RIV15-MSM-00159816
rdf:type
n4:Vysledek skos:Concept
dcterms:description
Background: Leptin-deficient animals hyperventilate. Leptin expression by adipocytes is attenuated by atrial natriuretic peptide (ANP). Increased circulating natriuretic peptides (NPs) are associated with an increased risk of central sleep apnea (CSA). This study tested whether serum leptin concentration is inversely correlated to NP concentration and decreased in patients with heart failure (HF) and CSA. Methods: Subjects with HF (N = 29) were studied by measuring leptin, NPs, CO2 chemosensitivity (Delta minute ventilation [(V) over dotE]/Delta partial pressure of end-tidal CO2 [PETCO2]), and ventilatory efficiency ((V) over dotE/CO2 output [(V) over dotO(2)]) and were classified as CSA or no sleep-disordered breathing by polysomnography. CSA was defined as a central apnea-hypopnea index >= 15. The Student t test, Mann-Whitney U test, and logistic regression were used for analysis, and data were summarized as mean +/- SD; P < .05 was considered significant. Results: Subjects with CSA had higher ANP and brain natriuretic peptide (BNP) concentrations (P < .05), Delta(V) over dotE/Delta PETCO2 (2.39 +/- 1.03 L/min/mm Hg vs 1.54 +/- 0.35 L/min/mm Hg, P = .01), and (V) over dotE/(V) over dotCO(2) (43 +/- 9 vs 34 +/- 7, P < .01) and lower leptin concentrations (8 +/- 10.7 ng/mL vs 17.1 +/- 8.8 ng/mL, P < .01). Logistic regression analysis (adjusted for age, sex, and BMI) demonstrated leptin (OR = 0.07; 95% CI, 0.01-0.71; P = .04) and BNP (OR = 4.45; 95% CI, 1.1-17.9; P = .05) to be independently associated with CSA. Conclusions: In patients with HF and CSA, leptin concentration is low and is inversely related to NP concentration. Counterregulatory interactions of leptin and NP may be important in ventilatory control in HF. Background: Leptin-deficient animals hyperventilate. Leptin expression by adipocytes is attenuated by atrial natriuretic peptide (ANP). Increased circulating natriuretic peptides (NPs) are associated with an increased risk of central sleep apnea (CSA). This study tested whether serum leptin concentration is inversely correlated to NP concentration and decreased in patients with heart failure (HF) and CSA. Methods: Subjects with HF (N = 29) were studied by measuring leptin, NPs, CO2 chemosensitivity (Delta minute ventilation [(V) over dotE]/Delta partial pressure of end-tidal CO2 [PETCO2]), and ventilatory efficiency ((V) over dotE/CO2 output [(V) over dotO(2)]) and were classified as CSA or no sleep-disordered breathing by polysomnography. CSA was defined as a central apnea-hypopnea index >= 15. The Student t test, Mann-Whitney U test, and logistic regression were used for analysis, and data were summarized as mean +/- SD; P < .05 was considered significant. Results: Subjects with CSA had higher ANP and brain natriuretic peptide (BNP) concentrations (P < .05), Delta(V) over dotE/Delta PETCO2 (2.39 +/- 1.03 L/min/mm Hg vs 1.54 +/- 0.35 L/min/mm Hg, P = .01), and (V) over dotE/(V) over dotCO(2) (43 +/- 9 vs 34 +/- 7, P < .01) and lower leptin concentrations (8 +/- 10.7 ng/mL vs 17.1 +/- 8.8 ng/mL, P < .01). Logistic regression analysis (adjusted for age, sex, and BMI) demonstrated leptin (OR = 0.07; 95% CI, 0.01-0.71; P = .04) and BNP (OR = 4.45; 95% CI, 1.1-17.9; P = .05) to be independently associated with CSA. Conclusions: In patients with HF and CSA, leptin concentration is low and is inversely related to NP concentration. Counterregulatory interactions of leptin and NP may be important in ventilatory control in HF.
dcterms:title
Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure
skos:prefLabel
Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure
skos:notation
RIV/00159816:_____/14:00060944!RIV15-MSM-00159816
n5:aktivita
n18:P
n5:aktivity
P(ED1.100/02/0123)
n5:cisloPeriodika
1
n5:dodaniDat
n11:2015
n5:domaciTvurceVysledku
n15:9298444
n5:druhVysledku
n7:J
n5:duvernostUdaju
n17:S
n5:entitaPredkladatele
n12:predkladatel
n5:idSjednocenehoVysledku
25989
n5:idVysledku
RIV/00159816:_____/14:00060944
n5:jazykVysledku
n8:eng
n5:klicovaSlova
release; mechanism; cardiology; testosterone; exercise; association; ob/ob mice; cardiovascular-disease; ventilatory response; atrial-natriuretic-peptide
n5:klicoveSlovo
n6:atrial-natriuretic-peptide n6:mechanism n6:ventilatory%20response n6:cardiology n6:cardiovascular-disease n6:exercise n6:release n6:testosterone n6:ob%2Fob%20mice n6:association
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[EE47C8FD8A59]
n5:nazevZdroje
Chest
n5:obor
n14:FA
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
7
n5:projekt
n10:ED1.100%2F02%2F0123
n5:rokUplatneniVysledku
n11:2014
n5:svazekPeriodika
145
n5:tvurceVysledku
Scott, Christopher G. Van Der Walt, Christelle Somers, Virend K. Čundrle, Ivan Johnson, Bruce D. Singh, Prachi Olson, Lyle J.
n5:wos
000329966300020
s:issn
0012-3692
s:numberOfPages
7
n3:doi
10.1378/chest.12-2914