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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F13%3A00061135%21RIV15-MSM-00159816
rdf:type
n10:Vysledek skos:Concept
dcterms:description
BACKGROUND: Remote ischemic preconditioning (RIPC) is the application of a transient and brief ischemic stimulus to a distant site from the organ or tissue that is afterward exposed to injury ischemia, and has been found to reduce ischemia-reperfusion injury (IRI) in various animal models. RIPC appears to offer two distinct phases of endothelial IRI protection, which are presumably mediated through neuronal and humoral pathways. METHODS: We conducted a comprehensive literature review on the available published data about the potential effect of RIPC in patients undergoing IRI in one or more vital organs. RESULTS: Our search highlighted 24 randomized clinical trials about the effect of RIPC on variable clinical settings (abdominal aortic aneurysm repair, open heart surgery, percutaneous coronary intervention, living donor renal transplantation, coronary angiography, elective decompression surgery, carotid endarterectomy, recent stroke, or transient ischemic attack combined with intracranial carotid artery stenosis). Most of the trials focused on postoperative cardiac or renal function after RIPC with conflicting results. Preconditioning protocols, age limits, comorbidities, and concomitant drug use varied significantly across trials, and therefore no firm conclusions can be drawn using the available data. However, no severe local adverse events were observed in any patient undergoing limb or arm preconditioning. CONCLUSIONS: RIPC is a safe and well-tolerated procedure that may constitute a potentially promising innovative treatment in atherosclerotic diseases. Large, multicenter, randomized clinical trials are required to determine an optimal protocol for the RIPC procedure, and to evaluate further the potential benefits of RIPC in human ischemic injury. BACKGROUND: Remote ischemic preconditioning (RIPC) is the application of a transient and brief ischemic stimulus to a distant site from the organ or tissue that is afterward exposed to injury ischemia, and has been found to reduce ischemia-reperfusion injury (IRI) in various animal models. RIPC appears to offer two distinct phases of endothelial IRI protection, which are presumably mediated through neuronal and humoral pathways. METHODS: We conducted a comprehensive literature review on the available published data about the potential effect of RIPC in patients undergoing IRI in one or more vital organs. RESULTS: Our search highlighted 24 randomized clinical trials about the effect of RIPC on variable clinical settings (abdominal aortic aneurysm repair, open heart surgery, percutaneous coronary intervention, living donor renal transplantation, coronary angiography, elective decompression surgery, carotid endarterectomy, recent stroke, or transient ischemic attack combined with intracranial carotid artery stenosis). Most of the trials focused on postoperative cardiac or renal function after RIPC with conflicting results. Preconditioning protocols, age limits, comorbidities, and concomitant drug use varied significantly across trials, and therefore no firm conclusions can be drawn using the available data. However, no severe local adverse events were observed in any patient undergoing limb or arm preconditioning. CONCLUSIONS: RIPC is a safe and well-tolerated procedure that may constitute a potentially promising innovative treatment in atherosclerotic diseases. Large, multicenter, randomized clinical trials are required to determine an optimal protocol for the RIPC procedure, and to evaluate further the potential benefits of RIPC in human ischemic injury.
dcterms:title
The role of remote ischemic preconditioning in the treatment of atherosclerotic diseases The role of remote ischemic preconditioning in the treatment of atherosclerotic diseases
skos:prefLabel
The role of remote ischemic preconditioning in the treatment of atherosclerotic diseases The role of remote ischemic preconditioning in the treatment of atherosclerotic diseases
skos:notation
RIV/00159816:_____/13:00061135!RIV15-MSM-00159816
n4:aktivita
n12:P
n4:aktivity
P(ED1.100/02/0123)
n4:cisloPeriodika
6
n4:dodaniDat
n9:2015
n4:domaciTvurceVysledku
Tsivgoulis, Georgios
n4:druhVysledku
n8:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
103363
n4:idVysledku
RIV/00159816:_____/13:00061135
n4:jazykVysledku
n6:eng
n4:klicovaSlova
remote ischemic preconditioning; peripheral arterial disease; ischemic stroke; coronary artery disease; atherosclerosis; Aortic aneurysm
n4:klicoveSlovo
n5:ischemic%20stroke n5:remote%20ischemic%20preconditioning n5:peripheral%20arterial%20disease n5:atherosclerosis n5:Aortic%20aneurysm n5:coronary%20artery%20disease
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[FE522188C2D6]
n4:nazevZdroje
Brain and Behavior
n4:obor
n13:FH
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
8
n4:projekt
n16:ED1.100%2F02%2F0123
n4:rokUplatneniVysledku
n9:2013
n4:svazekPeriodika
3
n4:tvurceVysledku
Vasdekis, S.N Martikos, G. Lazaris, A. Athanasiadis, D. Machairas, A. Tsivgoulis, Georgios Katsanos, A.H Liakakos, T.
n4:wos
000346972200002
s:issn
2162-3279
s:numberOfPages
11
n17:doi
10.1002/brb3.161