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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F13%3A00060681%21RIV14-MZ0-00159816
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Context Hypothermia is known to influence thromboelastography (TEG). TEG reproducibility is generally low. Objective The aim of this study was to evaluate the rationale of TEG temperature adjustment in patients during hypothermia. We hypothesised that temperature adjustment would not be important because of low TEG reproducibility. Design Prospective observational study. Setting Single-centre, secondary care study performed 01/2009 to 07/2010. Patients Survivors of cardiopulmonary resuscitation in whom therapeutic hypothermia (32 to 34 degrees C) was indicated for 24 h were recruited to the study which lasted 36 h. Four hundred samples from 30 patients (22 men and eight women) were obtained. No specific exclusion criteria were defined. Main outcome measures Temperature adjusted and non-adjusted Kaolin-Heparinase and Rapid-TEG were done at 12-h intervals during the first 36 h. Results Bland-Altman plots were used for analysis. During hypothermia, the bias of adjusted measurements was greater in clot formation variables for both Kaolin-Heparinase-TEG (from -15 to -19%) and Rapid-TEG (-9 to -25%) compared to normothermia (from -3 to 3% for Kaolin-Heparinase-TEG and -10 to 2% for Rapid-TEG). Bias of clot strength variables was not influenced by temperature adjustment (median -1%). The 95% limits of agreement were wide for clot formation variables and independent of temperature. Context Hypothermia is known to influence thromboelastography (TEG). TEG reproducibility is generally low. Objective The aim of this study was to evaluate the rationale of TEG temperature adjustment in patients during hypothermia. We hypothesised that temperature adjustment would not be important because of low TEG reproducibility. Design Prospective observational study. Setting Single-centre, secondary care study performed 01/2009 to 07/2010. Patients Survivors of cardiopulmonary resuscitation in whom therapeutic hypothermia (32 to 34 degrees C) was indicated for 24 h were recruited to the study which lasted 36 h. Four hundred samples from 30 patients (22 men and eight women) were obtained. No specific exclusion criteria were defined. Main outcome measures Temperature adjusted and non-adjusted Kaolin-Heparinase and Rapid-TEG were done at 12-h intervals during the first 36 h. Results Bland-Altman plots were used for analysis. During hypothermia, the bias of adjusted measurements was greater in clot formation variables for both Kaolin-Heparinase-TEG (from -15 to -19%) and Rapid-TEG (-9 to -25%) compared to normothermia (from -3 to 3% for Kaolin-Heparinase-TEG and -10 to 2% for Rapid-TEG). Bias of clot strength variables was not influenced by temperature adjustment (median -1%). The 95% limits of agreement were wide for clot formation variables and independent of temperature.
dcterms:title
Temperature corrected thromboelastography in hypothermia. Is it necessary? Temperature corrected thromboelastography in hypothermia. Is it necessary?
skos:prefLabel
Temperature corrected thromboelastography in hypothermia. Is it necessary? Temperature corrected thromboelastography in hypothermia. Is it necessary?
skos:notation
RIV/00159816:_____/13:00060681!RIV14-MZ0-00159816
n10:predkladatel
n18:ico%3A00159816
n3:aktivita
n12:P n12:I
n3:aktivity
I, P(NS10097)
n3:cisloPeriodika
2
n3:dodaniDat
n17:2014
n3:domaciTvurceVysledku
n4:5614902 n4:9298444 n4:1852698 n4:6665527
n3:druhVysledku
n7:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
110248
n3:idVysledku
RIV/00159816:_____/13:00060681
n3:jazykVysledku
n14:eng
n3:klicovaSlova
thromboelastography; hypothermia; cardiopulmonary resuscitation
n3:klicoveSlovo
n5:hypothermia n5:cardiopulmonary%20resuscitation n5:thromboelastography
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[520090EDEDCB]
n3:nazevZdroje
European journal of anaesthesiology
n3:obor
n13:FP
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:projekt
n11:NS10097
n3:rokUplatneniVysledku
n17:2013
n3:svazekPeriodika
30
n3:tvurceVysledku
Pavlik, Martin Zvoníček, Václav Suk, Pavel Radouskova, Iveta Čundrle, Ivan Šrámek, Vladimír
n3:wos
000313497200008
s:issn
0265-0215
s:numberOfPages
5
n6:doi
10.1097/EJA.0b013e32835c3716