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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F13%3A00060618%21RIV14-MZ0-00159816
rdf:type
n7:Vysledek skos:Concept
dcterms:description
The potential effect of age and gender stratification in the outcome of patients with carotid artery stenosis undergoing carotid revascularization procedures (CRP) may have important implications in clinical practice. Both European Stroke Organization and American Heart Association guidelines suggest that age and sex should be taken into account when selecting a CRP for an individual patient. We reviewed available literature data through Medline and Embase. Our search was based on the combination of terms: age, gender, sex, carotid artery stenosis, carotid artery stenting (CAS) and carotid endarterectomy (CEA). Postoperative stroke and mortality rates increased with age after any CRP (CEA or CAS), especially in patients aged over 75 years. Older patients with carotid artery stenosis undergoing CAS were found to have a nearly double risk of stroke or death compared with CEA, while CEA was found to benefit more patients aged over 70 years with symptomatic carotid artery stenosis. Male patients with symptomatic or asymptomatic carotid artery stenosis had lower stroke/mortality rates and benefited more from CEA compared with females. For the periprocedural risk of stroke or death in patients with carotid artery stenosis after CAS no sex differences were found. Therefore, CEA appears to have lower perioperative risks than CAS in patients aged over 70 years, and thus should be the treatment of choice if not contraindicated. The periprocedural risk of CEA is lower in men than in women, while there was no effect of gender on the periprocedural risk of CAS. The potential effect of age and gender stratification in the outcome of patients with carotid artery stenosis undergoing carotid revascularization procedures (CRP) may have important implications in clinical practice. Both European Stroke Organization and American Heart Association guidelines suggest that age and sex should be taken into account when selecting a CRP for an individual patient. We reviewed available literature data through Medline and Embase. Our search was based on the combination of terms: age, gender, sex, carotid artery stenosis, carotid artery stenting (CAS) and carotid endarterectomy (CEA). Postoperative stroke and mortality rates increased with age after any CRP (CEA or CAS), especially in patients aged over 75 years. Older patients with carotid artery stenosis undergoing CAS were found to have a nearly double risk of stroke or death compared with CEA, while CEA was found to benefit more patients aged over 70 years with symptomatic carotid artery stenosis. Male patients with symptomatic or asymptomatic carotid artery stenosis had lower stroke/mortality rates and benefited more from CEA compared with females. For the periprocedural risk of stroke or death in patients with carotid artery stenosis after CAS no sex differences were found. Therefore, CEA appears to have lower perioperative risks than CAS in patients aged over 70 years, and thus should be the treatment of choice if not contraindicated. The periprocedural risk of CEA is lower in men than in women, while there was no effect of gender on the periprocedural risk of CAS.
dcterms:title
Age and gender disparities in the risk of carotid revascularization procedures Age and gender disparities in the risk of carotid revascularization procedures
skos:prefLabel
Age and gender disparities in the risk of carotid revascularization procedures Age and gender disparities in the risk of carotid revascularization procedures
skos:notation
RIV/00159816:_____/13:00060618!RIV14-MZ0-00159816
n7:predkladatel
n8:ico%3A00159816
n3:aktivita
n10:I n10:P
n3:aktivity
I, P(ED1.100/02/0123)
n3:cisloPeriodika
10
n3:dodaniDat
n16:2014
n3:domaciTvurceVysledku
Tsivgoulis, Georgios
n3:druhVysledku
n15:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
59712
n3:idVysledku
RIV/00159816:_____/13:00060618
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Carotid artery stenting; Carotid endarterectomy; Disparities; Gender; Age
n3:klicoveSlovo
n6:Gender n6:Age n6:Disparities n6:Carotid%20endarterectomy n6:Carotid%20artery%20stenting
n3:kodStatuVydavatele
IT - Italská republika
n3:kontrolniKodProRIV
[44E37D821596]
n3:nazevZdroje
Neurological sciences
n3:obor
n18:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n13:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n16:2013
n3:svazekPeriodika
34
n3:tvurceVysledku
Vasdekis, Spyros N. Voumvourakis, Konstantinos Giannopoulos, Sotirios Boviatsis, Efstathios Katsanos, Aristeidis Tsivgoulis, Georgios
n3:wos
000325848300001
s:issn
1590-1874
s:numberOfPages
7
n5:doi
10.1007/s10072-013-1453-2