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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F13%3A00060589%21RIV14-MSM-00159816
rdf:type
skos:Concept n9:Vysledek
dcterms:description
Emerging medical nanotechnology applications often utilize magnetic forces to guide the movement of superparamagnetic particle linked cells and drugs in order to achieve a therapeutic effect. Superparamagnetic particle labeled endothelial cells have previously been captured on the surface of prototype nickel-plated stents in proof of concept studies. Facilitated endothelialization may help improve the healing of stented arteries and reduce the risk of stent thrombosis and restenosis. Extensive evaluation of candidate materials led to the development of a magnetizable 2205 duplex stainless steel stent. Magnetic field strengths of approximately 630 mG were induced within these stents by holding them in close proximity to a 0.7 T rare earth magnet. The magnetic field strength was reliably maintained over several days, but was partially reduced upon mild mechanical shock or plastic deformation. Mechanical testing demonstrated that stents could withstand crimping and expansion necessary for vascular implantation; however, magnetic field strength was significantly reduced. When placed in an endothelial cell suspension of 1 x 10(6) cells/mL, magnetized stents captured approximately 310 cells/mm(2) compared to approximately 35 cells/mm(2) for non-magnetized control stents. These data provide quantitative support to the observation that low level magnetization of stentsmay be adequate to attract labeled, autologous, blood-derived endothelial outgrowth cells following stent placement. This, in turn, may lead to more rapid and complete healing of stented arteries with a concomitant improvement in stent performance. Emerging medical nanotechnology applications often utilize magnetic forces to guide the movement of superparamagnetic particle linked cells and drugs in order to achieve a therapeutic effect. Superparamagnetic particle labeled endothelial cells have previously been captured on the surface of prototype nickel-plated stents in proof of concept studies. Facilitated endothelialization may help improve the healing of stented arteries and reduce the risk of stent thrombosis and restenosis. Extensive evaluation of candidate materials led to the development of a magnetizable 2205 duplex stainless steel stent. Magnetic field strengths of approximately 630 mG were induced within these stents by holding them in close proximity to a 0.7 T rare earth magnet. The magnetic field strength was reliably maintained over several days, but was partially reduced upon mild mechanical shock or plastic deformation. Mechanical testing demonstrated that stents could withstand crimping and expansion necessary for vascular implantation; however, magnetic field strength was significantly reduced. When placed in an endothelial cell suspension of 1 x 10(6) cells/mL, magnetized stents captured approximately 310 cells/mm(2) compared to approximately 35 cells/mm(2) for non-magnetized control stents. These data provide quantitative support to the observation that low level magnetization of stentsmay be adequate to attract labeled, autologous, blood-derived endothelial outgrowth cells following stent placement. This, in turn, may lead to more rapid and complete healing of stented arteries with a concomitant improvement in stent performance.
dcterms:title
Magnetizable Duplex Steel Stents Enable Endothelial Cell Capture Magnetizable Duplex Steel Stents Enable Endothelial Cell Capture
skos:prefLabel
Magnetizable Duplex Steel Stents Enable Endothelial Cell Capture Magnetizable Duplex Steel Stents Enable Endothelial Cell Capture
skos:notation
RIV/00159816:_____/13:00060589!RIV14-MSM-00159816
n9:predkladatel
n10:ico%3A00159816
n3:aktivita
n19:P
n3:aktivity
P(ED1.100/02/0123)
n3:cisloPeriodika
1
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n13:6986099
n3:druhVysledku
n17:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
85746
n3:idVysledku
RIV/00159816:_____/13:00060589
n3:jazykVysledku
n18:eng
n3:klicovaSlova
stents; magnetic; Endothelial cells
n3:klicoveSlovo
n8:Endothelial%20cells n8:stents n8:magnetic
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A7BAA536B427]
n3:nazevZdroje
IEEE Transactions on Magnetics
n3:obor
n12:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:projekt
n16:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n7:2013
n3:svazekPeriodika
49
n3:tvurceVysledku
Uthamaraj, Susheil Sandhu, Gurpreet S. Gooden, Janelle Y. Harburn, J. Jonathan Dragomir-Daescu, Dan Klabusay, Martin Holmes, David R., Jr. Simari, Robert D. Tefft, Brandon J.
n3:wos
000312831500052
s:issn
0018-9464
s:numberOfPages
4
n11:doi
10.1109/TMAG.2012.2224326