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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F12%3A%230001025%21RIV13-MZ0-00159816
rdf:type
skos:Concept n5:Vysledek
dcterms:description
This study was conducted to determine the incidence of grey-white matter abnormalities (GWMAs) on magnetic resonance images (MRIs) in patients with hippocampal sclerosis (HS), to assess the inter-observer reliability of this finding, and to establish a possible relationship between GWMA and histopathological findings in the anterior part of the temporal lobe, as well as its other relation to clinical variables. We established a group of 55 patients with histologically proven HS. Three observers independently reviewed the MRIs to assess whether GWMA was present. Substantial independent inter-observer agreement was reached for 44 of the 55 patients (80%) (Fleiss' kappa 0.732; p<0.0001). GWMAs were present in 38% of patients (HS + GWMA). Focal cortical dysplasia (FCD) of type Illa (ILAE classification) was present in 31% of patients. FCD type Illa was present in 52.4% with HS + GWMA, and in 17.6% without GWMA (HS - GWMA) (p=0.007). We did not find any statistically significant differences in the postoperative outcomes between HS + GWMA and HS - GWMA. We did not find any statistically significant differences in the presence or absence of GWMA and FCD of the temporal pole in relation to the onset of epilepsy, the duration of epilepsy, or the presence of potential epileptogenic insults. GWMA in the anterior part of temporal lobe in patients with HS is a reliable assessment sign for observers who are experienced in evaluating the MRIs of epilepsy patients. The presence of GWMA is significantly associated with the presence of FCD type Illa in these patients. The presence or absence of GWMA and FCD type Illa does not influence the postoperative outcome of HS patients. (C) 2012 Elsevier B.V. All rights reserved. This study was conducted to determine the incidence of grey-white matter abnormalities (GWMAs) on magnetic resonance images (MRIs) in patients with hippocampal sclerosis (HS), to assess the inter-observer reliability of this finding, and to establish a possible relationship between GWMA and histopathological findings in the anterior part of the temporal lobe, as well as its other relation to clinical variables. We established a group of 55 patients with histologically proven HS. Three observers independently reviewed the MRIs to assess whether GWMA was present. Substantial independent inter-observer agreement was reached for 44 of the 55 patients (80%) (Fleiss' kappa 0.732; p<0.0001). GWMAs were present in 38% of patients (HS + GWMA). Focal cortical dysplasia (FCD) of type Illa (ILAE classification) was present in 31% of patients. FCD type Illa was present in 52.4% with HS + GWMA, and in 17.6% without GWMA (HS - GWMA) (p=0.007). We did not find any statistically significant differences in the postoperative outcomes between HS + GWMA and HS - GWMA. We did not find any statistically significant differences in the presence or absence of GWMA and FCD of the temporal pole in relation to the onset of epilepsy, the duration of epilepsy, or the presence of potential epileptogenic insults. GWMA in the anterior part of temporal lobe in patients with HS is a reliable assessment sign for observers who are experienced in evaluating the MRIs of epilepsy patients. The presence of GWMA is significantly associated with the presence of FCD type Illa in these patients. The presence or absence of GWMA and FCD type Illa does not influence the postoperative outcome of HS patients. (C) 2012 Elsevier B.V. All rights reserved.
dcterms:title
Grey—white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables Grey—white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables
skos:prefLabel
Grey—white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables Grey—white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables
skos:notation
RIV/00159816:_____/12:#0001025!RIV13-MZ0-00159816
n5:predkladatel
n6:ico%3A00159816
n3:aktivita
n10:I
n3:aktivity
I
n3:cisloPeriodika
1-2
n3:dodaniDat
n9:2013
n3:domaciTvurceVysledku
n8:4235991 n8:9233075 n8:4716116 n8:4632907 n8:2299690 n8:3864871 n8:8132208
n3:druhVysledku
n11:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
138450
n3:idVysledku
RIV/00159816:_____/12:#0001025
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Grey–white matter abnormalities, Temporal lobe epilepsy, Focal cortical dysplasia, MRI
n3:klicoveSlovo
n4:MRI n4:Temporal%20lobe%20epilepsy n4:Grey%E2%80%93white%20matter%20abnormalities n4:Focal%20cortical%20dysplasia
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[07BB99127EEF]
n3:nazevZdroje
Epilepsy Research
n3:obor
n14:FH
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n9:2012
n3:svazekPeriodika
102
n3:tvurceVysledku
Horáková, Iva Brázdil, Milan Rektor, Ivan Pažourková, Marta Kuba, Robert Hermanová, Markéta Tyrlíková, Ivana
n3:wos
000311529400009
s:issn
0920-1211
s:numberOfPages
8
n17:doi
10.1016/j.eplepsyres.2012.05.002