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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F12%3A%230000980%21RIV13-MSM-00159816
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Alzheimer's disease (AD) represents a highly common form of dementia, but can be diagnosed in the earlier stages before dementia onset. Early diagnosis is crucial for successful therapeutic intervention. The introduction of new diagnostic biomarkers for AD is aimed at detecting underlying brain pathology. These biomarkers reflect structural or biochemical changes related to AD. Examination of cerebrospinal fluid has many drawbacks; therefore, the search for sensitive and specific blood markers is ongoing. Investigation is mainly focused on upstream processes, among which oxidative stress in the brain is of particular interest. Products of oxidative stress may diffuse into the blood and evaluating them can contribute to diagnosis of AD. However, results of blood oxidative stress markers are not consistent among various studies, as documented in this review. To find a specific biochemical marker for AD, we should concentrate on specific metabolic products formed in the brain. Specific fluorescent intermediates of brain lipid peroxidation may represent such candidates as the composition of brain phospholipids is unique. They are small lipophilic molecules and can diffuse into the blood stream, where they can then be detected. We propose that these fluorescent products are potential candidates for blood biomarkers of AD. Alzheimer's disease (AD) represents a highly common form of dementia, but can be diagnosed in the earlier stages before dementia onset. Early diagnosis is crucial for successful therapeutic intervention. The introduction of new diagnostic biomarkers for AD is aimed at detecting underlying brain pathology. These biomarkers reflect structural or biochemical changes related to AD. Examination of cerebrospinal fluid has many drawbacks; therefore, the search for sensitive and specific blood markers is ongoing. Investigation is mainly focused on upstream processes, among which oxidative stress in the brain is of particular interest. Products of oxidative stress may diffuse into the blood and evaluating them can contribute to diagnosis of AD. However, results of blood oxidative stress markers are not consistent among various studies, as documented in this review. To find a specific biochemical marker for AD, we should concentrate on specific metabolic products formed in the brain. Specific fluorescent intermediates of brain lipid peroxidation may represent such candidates as the composition of brain phospholipids is unique. They are small lipophilic molecules and can diffuse into the blood stream, where they can then be detected. We propose that these fluorescent products are potential candidates for blood biomarkers of AD.
dcterms:title
Blood Markers of Oxidative Stress in Alzheimer's Disease Blood Markers of Oxidative Stress in Alzheimer's Disease
skos:prefLabel
Blood Markers of Oxidative Stress in Alzheimer's Disease Blood Markers of Oxidative Stress in Alzheimer's Disease
skos:notation
RIV/00159816:_____/12:#0000980!RIV13-MSM-00159816
n15:predkladatel
n19:ico%3A00159816
n3:aktivita
n4:P
n3:aktivity
P(ED1.100/02/0123), P(GA309/09/1053), P(GP303/09/P049), P(NS10331)
n3:cisloPeriodika
10
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n18:5878276
n3:druhVysledku
n7:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
125289
n3:idVysledku
RIV/00159816:_____/12:#0000980
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Alzheimer disease
n3:klicoveSlovo
n12:Alzheimer%20disease
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[55B993D6210B]
n3:nazevZdroje
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
n3:obor
n11:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:projekt
n14:GA309%2F09%2F1053 n14:ED1.100%2F02%2F0123 n14:NS10331 n14:GP303%2F09%2FP049
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
16
n3:tvurceVysledku
Hort, Jakub
n3:wos
000309237500005
s:issn
1582-1838
s:numberOfPages
10
n10:doi
10.1111/j.1582-4934.2012.01585.x