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Statements

Subject Item
n2:RIV%2F00159816%3A_____%2F08%3A%230000412%21RIV10-MZ0-00159816
rdf:type
n12:Vysledek skos:Concept
dcterms:description
20 wilde-type strains of P. aeruginosa forming a 24-hour old biofilm in TSB medium on 96-well polystyren microtiter plates were used. We tested eight antibiotics, namely aztreonam, ceftazidim, cefoperazon, cefepim, netilmicin, amikacin, ofloxacin and ciprofloxacin, individually and in combinations. Minimum biofilm inhibitory concentration (MBIC) and fractionate inhibitory concentration (FBIC) were determined. Although in biofilm was P. aeruginosa less susceptible to antibiotics synergy due to 10 P. aeruginosa isolates were demonstrated for Aztreonam and Ciprofloxacin. Synergy was demonstrated also in case of b-lactams and aminoglycosides, b-lactams and fluoroquinolones, aminoglycosides and fluoroquinolones as well as for monobactams and b-lactams although the strains were resistant to the individual antibiotics. Synergism or partial synergism against 32.4 % of isolates with one or more antimicrobial combinations was found. 20 wilde-type strains of P. aeruginosa forming a 24-hour old biofilm in TSB medium on 96-well polystyren microtiter plates were used. We tested eight antibiotics, namely aztreonam, ceftazidim, cefoperazon, cefepim, netilmicin, amikacin, ofloxacin and ciprofloxacin, individually and in combinations. Minimum biofilm inhibitory concentration (MBIC) and fractionate inhibitory concentration (FBIC) were determined. Although in biofilm was P. aeruginosa less susceptible to antibiotics synergy due to 10 P. aeruginosa isolates were demonstrated for Aztreonam and Ciprofloxacin. Synergy was demonstrated also in case of b-lactams and aminoglycosides, b-lactams and fluoroquinolones, aminoglycosides and fluoroquinolones as well as for monobactams and b-lactams although the strains were resistant to the individual antibiotics. Synergism or partial synergism against 32.4 % of isolates with one or more antimicrobial combinations was found.
dcterms:title
Antibiotic synergy against Biofilm-Forming Pseudomonas aeruginosa Antibiotic synergy against Biofilm-Forming Pseudomonas aeruginosa
skos:prefLabel
Antibiotic synergy against Biofilm-Forming Pseudomonas aeruginosa Antibiotic synergy against Biofilm-Forming Pseudomonas aeruginosa
skos:notation
RIV/00159816:_____/08:#0000412!RIV10-MZ0-00159816
n4:aktivita
n14:P
n4:aktivity
P(NI6818)
n4:cisloPeriodika
1
n4:dodaniDat
n7:2010
n4:domaciTvurceVysledku
n13:4076834
n4:druhVysledku
n16:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
356389
n4:idVysledku
RIV/00159816:_____/08:#0000412
n4:jazykVysledku
n6:eng
n4:klicovaSlova
biofilm , antibioticsm, P. aeruginosa
n4:klicoveSlovo
n9:biofilm%20 n9:antibioticsm n9:P.%20aeruginosa
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[038000E9F2D7]
n4:nazevZdroje
Folia Microbiologica
n4:obor
n15:EE
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
2
n4:projekt
n5:NI6818
n4:rokUplatneniVysledku
n7:2008
n4:svazekPeriodika
53
n4:tvurceVysledku
Votava, Miroslav Černohorská, Lenka
s:issn
0015-5632
s:numberOfPages
96