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Statements

Subject Item
n2:RIV%2F00098892%3A_____%2F13%3A%230000425%21RIV14-MZ0-00098892
rdf:type
skos:Concept n7:Vysledek
dcterms:description
The aim of the present study was to evaluate the association between changes in peripheral blood cell count and neopterin concentrations in patients with a history of breast cancer. Peripheral blood cell count, serum ferritin, serum neopterin and urinary neopterin concentrations were determined in 61 patients with a history of breast cancer and 74 control subjects. Hemoglobin, relative lymphocyte count and absolute lymphocyte count were lower, and relative neutrophil count, ferritin and serum neopterin concentrations were significantly higher in breast cancer patients than in controls. Compared to controls, the difference in hemoglobin concentration was statistically significant only in patients with active disease. Significant negative correlations were observed between urinary neopterin and hemoglobin as well as between serum neopterin and relative lymphocyte counts in breast cancer patients. Increased ferritin concentrations were associated with a history of hypertension, but higher absolute lymphocyte counts were associated with hypertension only in subjects without history of cancer. In conclusion, in patients with a history of breast cancer, anemia is associated with disease activity and systemic immune activation. Ferritin concentrations are increased in subjects with hypertension. The aim of the present study was to evaluate the association between changes in peripheral blood cell count and neopterin concentrations in patients with a history of breast cancer. Peripheral blood cell count, serum ferritin, serum neopterin and urinary neopterin concentrations were determined in 61 patients with a history of breast cancer and 74 control subjects. Hemoglobin, relative lymphocyte count and absolute lymphocyte count were lower, and relative neutrophil count, ferritin and serum neopterin concentrations were significantly higher in breast cancer patients than in controls. Compared to controls, the difference in hemoglobin concentration was statistically significant only in patients with active disease. Significant negative correlations were observed between urinary neopterin and hemoglobin as well as between serum neopterin and relative lymphocyte counts in breast cancer patients. Increased ferritin concentrations were associated with a history of hypertension, but higher absolute lymphocyte counts were associated with hypertension only in subjects without history of cancer. In conclusion, in patients with a history of breast cancer, anemia is associated with disease activity and systemic immune activation. Ferritin concentrations are increased in subjects with hypertension.
dcterms:title
Systemic immune response and peripheral blood cell count in patients with a history of breast cancer Systemic immune response and peripheral blood cell count in patients with a history of breast cancer
skos:prefLabel
Systemic immune response and peripheral blood cell count in patients with a history of breast cancer Systemic immune response and peripheral blood cell count in patients with a history of breast cancer
skos:notation
RIV/00098892:_____/13:#0000425!RIV14-MZ0-00098892
n7:predkladatel
n8:ico%3A00098892
n3:aktivita
n14:P n14:I
n3:aktivity
I, P(NT13564)
n3:cisloPeriodika
3-4
n3:dodaniDat
n13:2014
n3:domaciTvurceVysledku
n9:8062587 n9:6392377 n9:3986659
n3:druhVysledku
n15:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
109695
n3:idVysledku
RIV/00098892:_____/13:#0000425
n3:jazykVysledku
n17:eng
n3:klicovaSlova
breast cancer, hemoglobin, neopterin
n3:klicoveSlovo
n4:neopterin n4:breast%20cancer n4:hemoglobin
n3:kodStatuVydavatele
AT - Rakouská republika
n3:kontrolniKodProRIV
[7F58B6D76DAF]
n3:nazevZdroje
Pteridines
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
11
n3:projekt
n16:NT13564
n3:rokUplatneniVysledku
n13:2013
n3:svazekPeriodika
24
n3:tvurceVysledku
Študentová, Hana Šrámek, Vlastislav Vrána, David
s:issn
0933-4807
s:numberOfPages
7