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Statements

Subject Item
n2:RIV%2F00064211%3A_____%2F12%3A%230000211%21RIV14-MZ0-00064211
rdf:type
skos:Concept n6:Vysledek
dcterms:description
The study describes the case of a patient with a clinical and histopathological diagnosis of pemphigus vulgaris accompanied by severe side-effects of combined immunosuppressive therapy, who achieved a remission of the disease with adalimumab. Pemphigus vulgaris is a chronic blistering disease of the skin and mucous membranes. Before corticosteroids were introduced, mortality was high. Corticosteroids are currently used as first-line therapy. To reduce the dose of corticosteroids, therapeutic combinations with corticosteroid-sparing immunosuppressive agents are used. The therapy brings a number of complications due to its side effects. To achieve a remission of the disease by treating our patient with combined immunosuppressives, we administered adalimumab and achieved a very good clinical response. The study describes the case of a patient with a clinical and histopathological diagnosis of pemphigus vulgaris accompanied by severe side-effects of combined immunosuppressive therapy, who achieved a remission of the disease with adalimumab. Pemphigus vulgaris is a chronic blistering disease of the skin and mucous membranes. Before corticosteroids were introduced, mortality was high. Corticosteroids are currently used as first-line therapy. To reduce the dose of corticosteroids, therapeutic combinations with corticosteroid-sparing immunosuppressive agents are used. The therapy brings a number of complications due to its side effects. To achieve a remission of the disease by treating our patient with combined immunosuppressives, we administered adalimumab and achieved a very good clinical response.
dcterms:title
Pemphigus vulgaris treated with adalimumab: case study Pemphigus vulgaris treated with adalimumab: case study
skos:prefLabel
Pemphigus vulgaris treated with adalimumab: case study Pemphigus vulgaris treated with adalimumab: case study
skos:notation
RIV/00064211:_____/12:#0000211!RIV14-MZ0-00064211
n6:predkladatel
n7:ico%3A00064211
n3:aktivita
n4:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n10:2014
n3:domaciTvurceVysledku
n8:7160259 n8:5791278 n8:9128255 n8:3899950
n3:druhVysledku
n18:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
158102
n3:idVysledku
RIV/00064211:_____/12:#0000211
n3:jazykVysledku
n11:eng
n3:klicovaSlova
adalimumab; biological therapy; corticosteroids; pemphigus vulgaris; infliximab
n3:klicoveSlovo
n5:pemphigus%20vulgaris n5:infliximab n5:adalimumab n5:corticosteroids n5:biological%20therapy
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[D9307DD7D8D1]
n3:nazevZdroje
Dermatologic Therapy
n3:obor
n16:FO
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n10:2012
n3:svazekPeriodika
25
n3:tvurceVysledku
Hecogová, Jana Vojáčková, Naděžda Fialová, Jorga Vaňousová, Daniela
n3:wos
000304088300011
s:issn
1396-0296
s:numberOfPages
3
n17:doi
10.1111/j.1529-8019.2012.01433.x