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Statements

Subject Item
n2:RIV%2F00064211%3A_____%2F11%3A%230000280%21RIV14-MZ0-00064211
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Tubulocystic renal carcinoma (TCRC) is a recently described neoplastic entity. To date, clinicopathological features on less than Cases diagnosed as TCRC were retrieved and reviewed from the routine and consultation files of the Pilsen tumour registry comprising over 20,000 cases of renal tumours. All patients were men, mean age 56 years (range 29-70). Features on computed tomography (CT) were in two cases Bosniak III, one IV and two were solid tumours. In four patients, nephrectomy was performed, and one patient underwent resection. At the time of surgery, two patients had metastases. In one case, both primary tumour and metastases were active on FDG positron emission tomography (PET)/CT. Both patients with metastatic disease were treated with sunitinib with partial response. One patient died 26 months postoperatively and the other patient is alive 5 months after surgery. Three patients with localized tumours are without evidence of disease 31, 28 and 7 months after surgery. In one case, the resected tumour was histologically combined with a papillary renal cell carcinoma (PRCC). TCRC occurs predominantly in men with a wide age range. TCRC frequently displays a cystic component which may render a radiological classification of Bosniak III or IV. FDG PET/CT is helpful in the detection of metastases. TCRC has definitive malignant potential. Our findings support a possible relationship to PRCC. The tyrosine kinase inhibitor sunitinib may be used a therapeutical agent with partial response and temporary effect. Tubulocystic renal carcinoma (TCRC) is a recently described neoplastic entity. To date, clinicopathological features on less than Cases diagnosed as TCRC were retrieved and reviewed from the routine and consultation files of the Pilsen tumour registry comprising over 20,000 cases of renal tumours. All patients were men, mean age 56 years (range 29-70). Features on computed tomography (CT) were in two cases Bosniak III, one IV and two were solid tumours. In four patients, nephrectomy was performed, and one patient underwent resection. At the time of surgery, two patients had metastases. In one case, both primary tumour and metastases were active on FDG positron emission tomography (PET)/CT. Both patients with metastatic disease were treated with sunitinib with partial response. One patient died 26 months postoperatively and the other patient is alive 5 months after surgery. Three patients with localized tumours are without evidence of disease 31, 28 and 7 months after surgery. In one case, the resected tumour was histologically combined with a papillary renal cell carcinoma (PRCC). TCRC occurs predominantly in men with a wide age range. TCRC frequently displays a cystic component which may render a radiological classification of Bosniak III or IV. FDG PET/CT is helpful in the detection of metastases. TCRC has definitive malignant potential. Our findings support a possible relationship to PRCC. The tyrosine kinase inhibitor sunitinib may be used a therapeutical agent with partial response and temporary effect.
dcterms:title
Tubulocystic renal carcinoma: a clinical perspective Tubulocystic renal carcinoma: a clinical perspective
skos:prefLabel
Tubulocystic renal carcinoma: a clinical perspective Tubulocystic renal carcinoma: a clinical perspective
skos:notation
RIV/00064211:_____/11:#0000280!RIV14-MZ0-00064211
n9:predkladatel
n10:ico%3A00064211
n4:aktivita
n19:Z n19:I
n4:aktivity
I, Z(MSM0021620819)
n4:cisloPeriodika
3
n4:dodaniDat
n7:2014
n4:domaciTvurceVysledku
n14:6136745
n4:druhVysledku
n6:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
236185
n4:idVysledku
RIV/00064211:_____/11:#0000280
n4:jazykVysledku
n8:eng
n4:klicovaSlova
perspective; clinical; carcinoma; Tubulocystic
n4:klicoveSlovo
n5:perspective n5:clinical n5:Tubulocystic n5:carcinoma
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[DA9EBFA0CAAC]
n4:nazevZdroje
World Journal of Urology
n4:obor
n11:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
14
n4:rokUplatneniVysledku
n7:2011
n4:svazekPeriodika
29
n4:tvurceVysledku
Michal, Michal Kreuzberg, Boris Ürge, Tomáš Petersson, Fredrik Breza, Ján Hes, Ondřej Mego, Michal Hyršl, Luboš Ertl, Viktor Horal, Milan Klečka, Jiří Ferda, Jiří Holečková, Petra Stránský, Petr
n4:wos
000290806800015
n4:zamer
n18:MSM0021620819
s:issn
0724-4983
s:numberOfPages
6
n15:doi
10.1007/s00345-010-0614-7