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Statements

Subject Item
n2:RIV%2F00064211%3A_____%2F11%3A%230000165%21RIV14-MZ0-00064211
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The objectives of our study were to analyse the frequency and functional status of HIV-specific CD8+ T cells and the expression of non-specific activation markers on CD8+ T cells in HIV+ patients. We examined 28 HIV+ patients, including 13 patients not receiving therapy complex antiretroviral therapy (cART) using ELISpot assay and flow cytometry with intracellular and MHC tetramer staining. The results suggested that the alterations of HIV-specific immunity are not influenced by the therapy of HIV infection; whereas, the non-specific chronic immune activation is down-regulated by cART. The objectives of our study were to analyse the frequency and functional status of HIV-specific CD8+ T cells and the expression of non-specific activation markers on CD8+ T cells in HIV+ patients. We examined 28 HIV+ patients, including 13 patients not receiving therapy complex antiretroviral therapy (cART) using ELISpot assay and flow cytometry with intracellular and MHC tetramer staining. The results suggested that the alterations of HIV-specific immunity are not influenced by the therapy of HIV infection; whereas, the non-specific chronic immune activation is down-regulated by cART.
dcterms:title
Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation
skos:prefLabel
Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation
skos:notation
RIV/00064211:_____/11:#0000165!RIV14-MZ0-00064211
n13:predkladatel
n16:ico%3A00064211
n3:aktivita
n11:Z n11:S n11:P n11:I
n3:aktivity
I, P(GD310/05/H533), S, Z(MSM0021620806)
n3:cisloPeriodika
2
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n5:5254485 n5:3039145 n5:5649617
n3:druhVysledku
n4:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
186501
n3:idVysledku
RIV/00064211:_____/11:#0000165
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Antiretroviral therapy; CD38; HIV infection; HIV-specific CD8+ T cells; HLA-DR; Multifunctional CD8+ T cells
n3:klicoveSlovo
n14:Antiretroviral%20therapy n14:CD38 n14:Multifunctional%20CD8%2B%20T%20cells n14:HIV-specific%20CD8%2B%20T%20cells n14:HLA-DR n14:HIV%20infection
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[10D040EC414C]
n3:nazevZdroje
Current HIV Research
n3:obor
n19:FN
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n9:GD310%2F05%2FH533
n3:rokUplatneniVysledku
n15:2011
n3:svazekPeriodika
9
n3:tvurceVysledku
Bartovská, Zofia Rozsypal, Hanuš Holub, Michal Beran, Ondřej
n3:wos
000299645400003
n3:zamer
n18:MSM0021620806
s:issn
1570-162X
s:numberOfPages
7