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Statements

Subject Item
n2:RIV%2F00064211%3A_____%2F11%3A%230000160%21RIV14-MZ0-00064211
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Bacterial meningitis (BM) remains an infectious disease with a significant morbidity and mortality. The aim of this study was to describe the kinetics of cerebrospinal fluid (CSF) cortisol levels during BM and to assess its relationship to disease severity and etiology. A total of 55 patients with BM were enrolled in the study. Elevated CSF cortisol upon admission and its rapid decrease after starting therapy were associated with increased BM severity as assessed by the Acute Physiology and Chronic Health Evaluation II score, the Sequential Organ Failure Assessment score, Glasgow Coma Scale score and the Glasgow Outcome Scale score. The comparison of CSF cortisol according to BM etiology revealed a trend toward higher concentrations in meningitis caused by Streptococcus pneumoniae compared to Neisseria meningitidis. Our results demonstrate that the initially elevated CSF cortisol concentrations decrease rapidly after administration of BM therapy (i.e. antibiotics and dexamethasone). Bacterial meningitis (BM) remains an infectious disease with a significant morbidity and mortality. The aim of this study was to describe the kinetics of cerebrospinal fluid (CSF) cortisol levels during BM and to assess its relationship to disease severity and etiology. A total of 55 patients with BM were enrolled in the study. Elevated CSF cortisol upon admission and its rapid decrease after starting therapy were associated with increased BM severity as assessed by the Acute Physiology and Chronic Health Evaluation II score, the Sequential Organ Failure Assessment score, Glasgow Coma Scale score and the Glasgow Outcome Scale score. The comparison of CSF cortisol according to BM etiology revealed a trend toward higher concentrations in meningitis caused by Streptococcus pneumoniae compared to Neisseria meningitidis. Our results demonstrate that the initially elevated CSF cortisol concentrations decrease rapidly after administration of BM therapy (i.e. antibiotics and dexamethasone).
dcterms:title
Cortisol kinetics in cerebrospinal fluid during bacterial meningitis Cortisol kinetics in cerebrospinal fluid during bacterial meningitis
skos:prefLabel
Cortisol kinetics in cerebrospinal fluid during bacterial meningitis Cortisol kinetics in cerebrospinal fluid during bacterial meningitis
skos:notation
RIV/00064211:_____/11:#0000160!RIV14-MZ0-00064211
n13:predkladatel
n17:ico%3A00064211
n4:aktivita
n10:Z n10:I n10:P
n4:aktivity
I, P(NT11390), Z(MSM0021620806)
n4:cisloPeriodika
7
n4:dodaniDat
n18:2014
n4:domaciTvurceVysledku
n15:5649617 n15:3039145 n15:3740188
n4:druhVysledku
n14:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n20:predkladatel
n4:idSjednocenehoVysledku
192086
n4:idVysledku
RIV/00064211:_____/11:#0000160
n4:jazykVysledku
n16:eng
n4:klicovaSlova
Bacterial meningitis; Cerebrospinal fluid; Cortisol; Neisseria meningitidis; Streptococcus pneumoni
n4:klicoveSlovo
n5:Neisseria%20meningitidis n5:Streptococcus%20pneumoni n5:Cortisol n5:Cerebrospinal%20fluid n5:Bacterial%20meningitis
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[B339B14B1403]
n4:nazevZdroje
Journal of Clinical Neuroscience
n4:obor
n8:FN
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
3
n4:projekt
n7:NT11390
n4:rokUplatneniVysledku
n18:2011
n4:svazekPeriodika
18
n4:tvurceVysledku
Džupová, Olga Beran, Ondřej Holub, Michal
n4:wos
000292066700039
n4:zamer
n19:MSM0021620806
s:issn
0967-5868
s:numberOfPages
2
n3:doi
10.1016/j.jocn.2010.12.020