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Statements

Subject Item
n2:RIV%2F00064211%3A_____%2F11%3A%230000086%21RIV12-MZ0-00064211
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://www.springerlink.com/content/q471m578130715u9/
dcterms:description
PURPOSE: Timely knowledge of the bacterial etiology and localization of infection are important for empirical antibiotic therapy. Thus, the goal of this study was to evaluate routinely used biomarkers together with novel laboratory parameters in the diagnosis of infection. METHODS: In this prospective study, 54 adult patients with bacterial infections admitted to the Department of Infectious Diseases were included. For comparison, 27 patients with viral infections were enrolled. In these patients, white blood cell (WBC) counts, differential blood counts, serum levels of procalcitonin (PCT), IL-1β, IL-6, IL-8, IL-10, IL-12, TNF-α, IFN-γ, soluble CD14 (sCD14), heparin-binding protein (HBP), cortisol (Cort), and monocyte surface expression of TLR2, TLR4, HLA-DR, and CD14 were analyzed. Also, these biomarkers were evaluated in 21 patients with acute community-acquired bacterial pneumonia (CABP), as well as in 21 patients with pyelonephritis and urosepsis. RESULTS: The highest sensitivity and specificity (expressed as the area under the curve [AUC]) for bacterial infection were observed in serum concentration of PCT (0.952), neutrophil and lymphocyte counts (0.852 and 0.841, respectively), and serum levels of HBP (0.837), IL-6 (0.830), and Cort (0.817). In addition, the serum levels of IFN-γ and Cort were significantly higher and IL-8 levels were lower in CABP when compared to pyelonephritis or urosepsis. CONCLUSIONS: From the novel potential biomarkers, only PCT demonstrated superiority over the routine parameters in the differentiation of bacterial from viral infections. However, some of the novel parameters should be further evaluated in larger and better characterized cohorts of patients in order to find their clinical applications. PURPOSE: Timely knowledge of the bacterial etiology and localization of infection are important for empirical antibiotic therapy. Thus, the goal of this study was to evaluate routinely used biomarkers together with novel laboratory parameters in the diagnosis of infection. METHODS: In this prospective study, 54 adult patients with bacterial infections admitted to the Department of Infectious Diseases were included. For comparison, 27 patients with viral infections were enrolled. In these patients, white blood cell (WBC) counts, differential blood counts, serum levels of procalcitonin (PCT), IL-1β, IL-6, IL-8, IL-10, IL-12, TNF-α, IFN-γ, soluble CD14 (sCD14), heparin-binding protein (HBP), cortisol (Cort), and monocyte surface expression of TLR2, TLR4, HLA-DR, and CD14 were analyzed. Also, these biomarkers were evaluated in 21 patients with acute community-acquired bacterial pneumonia (CABP), as well as in 21 patients with pyelonephritis and urosepsis. RESULTS: The highest sensitivity and specificity (expressed as the area under the curve [AUC]) for bacterial infection were observed in serum concentration of PCT (0.952), neutrophil and lymphocyte counts (0.852 and 0.841, respectively), and serum levels of HBP (0.837), IL-6 (0.830), and Cort (0.817). In addition, the serum levels of IFN-γ and Cort were significantly higher and IL-8 levels were lower in CABP when compared to pyelonephritis or urosepsis. CONCLUSIONS: From the novel potential biomarkers, only PCT demonstrated superiority over the routine parameters in the differentiation of bacterial from viral infections. However, some of the novel parameters should be further evaluated in larger and better characterized cohorts of patients in order to find their clinical applications.
dcterms:title
Evaluation of potential biomarkers for the discrimination of bacterial and viral infections. Evaluation of potential biomarkers for the discrimination of bacterial and viral infections.
skos:prefLabel
Evaluation of potential biomarkers for the discrimination of bacterial and viral infections. Evaluation of potential biomarkers for the discrimination of bacterial and viral infections.
skos:notation
RIV/00064211:_____/11:#0000086!RIV12-MZ0-00064211
n12:predkladatel
n16:ico%3A00064211
n4:aktivita
n14:Z n14:P
n4:aktivity
P(NT11390), Z(MSM0021620806)
n4:cisloPeriodika
5
n4:dodaniDat
n7:2012
n4:domaciTvurceVysledku
n9:5649617 n9:6737374 n9:3039145
n4:druhVysledku
n18:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
198338
n4:idVysledku
RIV/00064211:_____/11:#0000086
n4:jazykVysledku
n17:eng
n4:klicovaSlova
Bacterial infection; Viral infection; Infectious focus; Biomarkers; Evaluation; Discrimination
n4:klicoveSlovo
n5:Evaluation n5:Bacterial%20infection n5:Biomarkers n5:Viral%20infection n5:Infectious%20focus n5:Discrimination
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[3B3E76CEE948]
n4:nazevZdroje
Infection
n4:obor
n13:FN
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
5
n4:projekt
n21:NT11390
n4:rokUplatneniVysledku
n7:2011
n4:svazekPeriodika
39
n4:tvurceVysledku
Karpíšková, Nikola Holub, Michal Herwald, Heiko Beran, Ondřej Chalupa, Pavel
n4:wos
000296843100004
n4:zamer
n20:MSM0021620806
s:issn
0300-8126
s:numberOfPages
7
n10:doi
10.1007/s15010-011-0126-4