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Statements

Subject Item
n2:RIV%2F00064211%3A_____%2F10%3A%230000066%21RIV11-MZ0-00064211
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Melanin production is the primary mechanism protecting human skin against the UV light-induced damage. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not only for melanocyte development, proliferation and survival, but also for the expression of enzymes and structural proteins ensuring the production of melanin. Here, we outline the mechanisms of transcriptional regulation of genes associated with the biosynthesis of melanin in melanocytes and melanoma cells. MITF is crucial in this process, while several other factors seem to have only an auxiliary role to play under specific circumstances. Melanin production is the primary mechanism protecting human skin against the UV light-induced damage. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not only for melanocyte development, proliferation and survival, but also for the expression of enzymes and structural proteins ensuring the production of melanin. Here, we outline the mechanisms of transcriptional regulation of genes associated with the biosynthesis of melanin in melanocytes and melanoma cells. MITF is crucial in this process, while several other factors seem to have only an auxiliary role to play under specific circumstances.
dcterms:title
%22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF. %22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF.
skos:prefLabel
%22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF. %22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF.
skos:notation
RIV/00064211:_____/10:#0000066!RIV11-MZ0-00064211
n3:aktivita
n15:Z n15:I n15:S n15:P
n3:aktivity
I, P(NR9319), S, Z(MSM0021620808)
n3:cisloPeriodika
7
n3:dodaniDat
n4:2011
n3:domaciTvurceVysledku
n16:8244618
n3:druhVysledku
n18:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
293275
n3:idVysledku
RIV/00064211:_____/10:#0000066
n3:jazykVysledku
n5:eng
n3:klicovaSlova
melanin; melanoma; microphthalmia; microphthalmia-associated transcription factor; pigmentation
n3:klicoveSlovo
n11:microphthalmia-associated%20transcription%20factor n11:pigmentation n11:melanoma n11:melanin n11:microphthalmia
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[9A495ABD39D7]
n3:nazevZdroje
Experimental dermatology
n3:obor
n14:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:projekt
n8:NR9319
n3:rokUplatneniVysledku
n4:2010
n3:svazekPeriodika
19
n3:tvurceVysledku
Borovanský, Jan Vachtenheim, Jiří
n3:zamer
n17:MSM0021620808
s:issn
0906-6705
s:numberOfPages
11