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Statements

Subject Item
n2:RIV%2F00064211%3A_____%2F04%3A00011449%21RIV%2F2005%2FMZ0%2FL10005%2FN
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Micropthtalmia transcription faktor (MITF) is crucial for the development of the melanocyte lineage and is overexpressed in malignant melanomas. The E1A protein is known to also exert an antitumor activity, which is associated with its transcription repression function and the ability to induce apoptosis and is a potential antimelanoma agent. We tested a direct repression of the melanocyte-specific MITF promoter by E1A and its mutants and we found that the extreme N-terminus and conserved region 1 are required for repression. Microphthalmia transkripční faktor (MITF) má rozhodující vliv ve vývoji melanocytových linií a u maligních melanomů je nadexprimovaný. Protein E1A je známý mimo jiné antitumorovou aktivitou, která je spojená s jeho transkripčně represorovou funkcí a schopností indukovat apoptózu a má potenciálně antimelanomové účinky. Testovali jsme přímou represi MITF-promotoru, specifického pro melanocyty, pomocí E1A a jeho mutant. Zjistili jsme, že N-koncová oblast a konzervovaná doména 1 jsou nezbytné pro tuto represi. Micropthtalmia transcription faktor (MITF) is crucial for the development of the melanocyte lineage and is overexpressed in malignant melanomas. The E1A protein is known to also exert an antitumor activity, which is associated with its transcription repression function and the ability to induce apoptosis and is a potential antimelanoma agent. We tested a direct repression of the melanocyte-specific MITF promoter by E1A and its mutants and we found that the extreme N-terminus and conserved region 1 are required for repression.
dcterms:title
Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein Represe melanocytově specifického promotoru microphthalmia-asociovaného transkripčního faktoru adenovirovým oncoproteinem E1A 12S Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein
skos:prefLabel
Represe melanocytově specifického promotoru microphthalmia-asociovaného transkripčního faktoru adenovirovým oncoproteinem E1A 12S Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein
skos:notation
RIV/00064211:_____/04:00011449!RIV/2005/MZ0/L10005/N
n4:strany
159-166
n4:aktivita
n12:Z
n4:aktivity
Z(MZ00000064211)
n4:cisloPeriodika
50
n4:dodaniDat
n9:2005
n4:domaciTvurceVysledku
n10:8244618
n4:druhVysledku
n16:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
584357
n4:idVysledku
RIV/00064211:_____/04:00011449
n4:jazykVysledku
n6:eng
n4:klicovaSlova
E1A;microphthalmia;MITF;melanoma;repression;0
n4:klicoveSlovo
n5:microphthalmia n5:MITF n5:repression n5:melanoma n5:E1A n5:0
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[A721CF32B818]
n4:nazevZdroje
FOLIA BIOLOGICA
n4:obor
n8:FD
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
2
n4:rokUplatneniVysledku
n9:2004
n4:svazekPeriodika
neuveden
n4:tvurceVysledku
Vachtenheim, Jiří Drdová, Blanka
n4:zamer
n17:MZ00000064211
s:issn
0015-5500
s:numberOfPages
8