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Statements

Subject Item
n2:RIV%2F00064211%3A_____%2F04%3A00011348%21RIV%2F2005%2FMZ0%2FL10005%2FN
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Stanovení prevalence GBV-c/HGV infekce u HIV pozitivních pacientů a zjišťování možného vlivu GBV-c/HGV na průběh infekce HIV stanovením imulogických a virologických markerů progrese HIV infekce. METODIKA: V roce 2002 a 2003 jsme vyšetřili séra u 273 HIV pozitivních pacientů z AIDS-centra FN Bulovka Praha na přítomnost markerů GBV-c/HGV infekce semikvantitativním stanovením HGV PCR a anti-E2 protilátek metodou ELISA. 271 sérových vzorků bylo vyšetřeno na HGV PCR a 269 vzorků na antiE2.V den odběru byla zjišťována HIV virémie a počet CD4 lymfocytů. Závislost počtu CD4 lymfocytů a virové nálože HIV na infekci virem HGV jsme zjišťovali Spearmanovým testem. VÝSLEDKY: 89 (33,3%) pacientů mělo pozitivní PCR HGV a 101 (38,5%) pacientů mělo pozitivní test anti-E2 metodou ELISA. Statisticky významný vliv GBV-c/HGV infekce u HIV infikovaných na počet CD4 lymfocytů a na virovou nálož HIV nebyl v našem souboru prokázán. ZÁVĚR: Naše sledování nepotvrzuje vliv GBV-c/HGV infekce na základni prediktivní laboratorní Objectives: Assessment of prevalence of GBV-c/HGV infection in HIV-infected patients and evaluating of a possible influence of GBV-c/HGV on the course of HIV infection by assessment of immunological and virological markers of progression of HIV infection. Methods: We have investigated seras of 273 HIV-infected patients from AIDS Center of the University Hospital Na Bulovce Prague during 2002-2003. Our target was to assess the presence of markers of GBV-c/HGV infection by semiquantitative HGV PCR evaluation and anti-E2 antibodies by ELISA testing. 271 of serum samples were tested for HGV PCR and 269 samples were tested for anti-E2 antibodies. HIV viral load and CD4 count were tested concurrently. We used Spearman´s test to rule out the dependency of CD4 count and HIV viral load on HGV infection. Results: 89 (33,3%) of patients were positive in PCR HGV test and 101 (38,5%) of patients were positive in anti E2-ELISA. No statistically significant efect of GBV-c/HGV infection was observed on CD4 count an Objectives: Assessment of prevalence of GBV-c/HGV infection in HIV-infected patients and evaluating of a possible influence of GBV-c/HGV on the course of HIV infection by assessment of immunological and virological markers of progression of HIV infection. Methods: We have investigated seras of 273 HIV-infected patients from AIDS Center of the University Hospital Na Bulovce Prague during 2002-2003. Our target was to assess the presence of markers of GBV-c/HGV infection by semiquantitative HGV PCR evaluation and anti-E2 antibodies by ELISA testing. 271 of serum samples were tested for HGV PCR and 269 samples were tested for anti-E2 antibodies. HIV viral load and CD4 count were tested concurrently. We used Spearman´s test to rule out the dependency of CD4 count and HIV viral load on HGV infection. Results: 89 (33,3%) of patients were positive in PCR HGV test and 101 (38,5%) of patients were positive in anti E2-ELISA. No statistically significant efect of GBV-c/HGV infection was observed on CD4 count an
dcterms:title
Prevalence of GBV-c/HGV in HIV-infected patients and potential influence of coinfection on the course of the disease. Prevalence of GBV-c/HGV in HIV-infected patients and potential influence of coinfection on the course of the disease. Prevalence of GBV-c/HGV in HIV-infected patients and potential influence of coinfection on the course of the disease./Prevalence GBV-c/HGV u HIV infikovaných pacientů a možný význam koinfekce pro vývoj nemoci
skos:prefLabel
Prevalence of GBV-c/HGV in HIV-infected patients and potential influence of coinfection on the course of the disease./Prevalence GBV-c/HGV u HIV infikovaných pacientů a možný význam koinfekce pro vývoj nemoci Prevalence of GBV-c/HGV in HIV-infected patients and potential influence of coinfection on the course of the disease. Prevalence of GBV-c/HGV in HIV-infected patients and potential influence of coinfection on the course of the disease.
skos:notation
RIV/00064211:_____/04:00011348!RIV/2005/MZ0/L10005/N
n4:strany
157-157
n4:aktivita
n12:P
n4:aktivity
P(NI7509)
n4:cisloPeriodika
suppl.3
n4:dodaniDat
n9:2005
n4:domaciTvurceVysledku
n11:9347615 n11:7105940 n11:1237950
n4:druhVysledku
n13:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
581651
n4:idVysledku
RIV/00064211:_____/04:00011348
n4:jazykVysledku
n8:eng
n4:klicovaSlova
prevalence;GBV/c/HGV;HIV;infected;patients;influence;coinfection;course;disease;immunological;virological;markers;progression;infection;273;infected;patients;AIDS;Center;Prague;viral;load;CD4;dependency;HGV PCR;33%;positive;anti-E2;38,5%;effect;predictiv
n4:klicoveSlovo
n5:coinfection n5:immunological n5:predictiv n5:progression n5:anti-E2 n5:AIDS n5:Center n5:virological n5:HIV n5:disease n5:HGV%20PCR n5:viral n5:patients n5:infected n5:load n5:infection n5:effect n5:positive n5:course n5:5%25 n5:dependency n5:Prague n5:33%25 n5:38 n5:markers n5:CD4 n5:273 n5:GBV%2Fc%2FHGV n5:prevalence n5:influence
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[4971C08A7426]
n4:nazevZdroje
Clinical Microbiology and Infection
n4:obor
n10:FN
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
5
n4:projekt
n15:NI7509
n4:rokUplatneniVysledku
n9:2004
n4:svazekPeriodika
10
n4:tvurceVysledku
Aster, Viktor König, Jaroslav Staňková, Marie Procházka, Bohumil Rozsypal, Hanuš
s:issn
1198-743X
s:numberOfPages
1