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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F13%3A10193311%21RIV14-MZ0-00064203
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://circ.ahajournals.org/content/127/5/613
dcterms:description
Background-We evaluated the effects of the site of ventricular pacing on left ventricular (LV) synchrony and function in children requiring permanent pacing. Methods and Results-One hundred seventy-eight children (aged < 18 years) from 21 centers with atrioventricular block and a structurally normal heart undergoing permanent pacing were studied cross-sectionally. Median age at evaluation was 11.2 (interquartile range, 6.3-15.0) years. Median pacing duration was 5.4 (interquartile range, 3.1-8.8) years. Pacing sites were the free wall of the right ventricular (RV) outflow tract (n=8), lateral RV (n=44), RV apex (n=61), RV septum (n=29), LV apex (n=12), LV midlateral wall (n=17), and LV base (n=7). LV synchrony, pump function, and contraction efficiency were significantly affected by pacing site and were superior in children paced at the LV apex/LV midlateral wall. LV dyssynchrony correlated inversely with LV ejection fraction (R=0.80, P=0.031). Pacing from the RV outflow tract/lateral RV predicted significantly decreased LV function (LV ejection fraction < 45%; odds ratio, 10.72; confidence interval, 2.07-55.60; P=0.005), whereas LV apex/LV midlateral wall pacing was associated with preserved LV function (LV ejection fraction }= 55%; odds ratio, 8.26; confidence interval, 1.46-47.62; P=0.018). Presence of maternal autoantibodies, gender, age at implantation, duration of pacing, DDD mode, and QRS duration had no significant impact on LV ejection fraction. Conclusions-The site of ventricular pacing has a major impact on LV mechanical synchrony, efficiency, and pump function in children who require lifelong pacing. Of the sites studied, LV apex/LV midlateral wall pacing has the greatest potential to prevent pacing-induced reduction of cardiac pump function. Background-We evaluated the effects of the site of ventricular pacing on left ventricular (LV) synchrony and function in children requiring permanent pacing. Methods and Results-One hundred seventy-eight children (aged < 18 years) from 21 centers with atrioventricular block and a structurally normal heart undergoing permanent pacing were studied cross-sectionally. Median age at evaluation was 11.2 (interquartile range, 6.3-15.0) years. Median pacing duration was 5.4 (interquartile range, 3.1-8.8) years. Pacing sites were the free wall of the right ventricular (RV) outflow tract (n=8), lateral RV (n=44), RV apex (n=61), RV septum (n=29), LV apex (n=12), LV midlateral wall (n=17), and LV base (n=7). LV synchrony, pump function, and contraction efficiency were significantly affected by pacing site and were superior in children paced at the LV apex/LV midlateral wall. LV dyssynchrony correlated inversely with LV ejection fraction (R=0.80, P=0.031). Pacing from the RV outflow tract/lateral RV predicted significantly decreased LV function (LV ejection fraction < 45%; odds ratio, 10.72; confidence interval, 2.07-55.60; P=0.005), whereas LV apex/LV midlateral wall pacing was associated with preserved LV function (LV ejection fraction }= 55%; odds ratio, 8.26; confidence interval, 1.46-47.62; P=0.018). Presence of maternal autoantibodies, gender, age at implantation, duration of pacing, DDD mode, and QRS duration had no significant impact on LV ejection fraction. Conclusions-The site of ventricular pacing has a major impact on LV mechanical synchrony, efficiency, and pump function in children who require lifelong pacing. Of the sites studied, LV apex/LV midlateral wall pacing has the greatest potential to prevent pacing-induced reduction of cardiac pump function.
dcterms:title
Permanent Cardiac Pacing in Children: Choosing the Optimal Pacing Site A Multicenter Study Permanent Cardiac Pacing in Children: Choosing the Optimal Pacing Site A Multicenter Study
skos:prefLabel
Permanent Cardiac Pacing in Children: Choosing the Optimal Pacing Site A Multicenter Study Permanent Cardiac Pacing in Children: Choosing the Optimal Pacing Site A Multicenter Study
skos:notation
RIV/00064203:_____/13:10193311!RIV14-MZ0-00064203
n12:predkladatel
n13:ico%3A00064203
n3:aktivita
n11:P
n3:aktivity
P(NT12321)
n3:cisloPeriodika
5
n3:dodaniDat
n19:2014
n3:domaciTvurceVysledku
n14:7025653 n14:1168851 n14:2104946
n3:druhVysledku
n10:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
95827
n3:idVysledku
RIV/00064203:_____/13:10193311
n3:jazykVysledku
n15:eng
n3:klicovaSlova
pediatrics; pacing; pacemakers; heart failure; heart block
n3:klicoveSlovo
n4:pacemakers n4:pediatrics n4:pacing n4:heart%20block n4:heart%20failure
n3:kodStatuVydavatele
AU - Australské společenství
n3:kontrolniKodProRIV
[E68A6E625F84]
n3:nazevZdroje
Circulation
n3:obor
n18:FA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
28
n3:projekt
n7:NT12321
n3:rokUplatneniVysledku
n19:2013
n3:svazekPeriodika
127
n3:tvurceVysledku
Krupičková, Sylvia Wren, Christopher Nuernberg, Jan-Hendrik Volaufova, Julia Hiippala, Anita Clur, Sally-Ann Friedberg, Mark Tomaske, Maren de Guillebon, Maxime Janoušek, Jan Prinzen, Frits W. Fruh, Andreas Tisma-Dupanovic, Svjetlana Papagiannis, John Nagel, Bert Gabbarini, Fulvio Kerst, Gunter Marek, Jan Delhaas, Tammo van Geldorp, Irene E. Rosenthal, Eric Frias, Patrick Ganame, Javier Gebauer, Roman A Tsao, Sabrina Elders, Jan Nugent, Kelly Kubuš, Peter
n3:wos
000314691700015
s:issn
0009-7322
s:numberOfPages
11
n8:doi
10.1161/CIRCULATIONAHA.112.115428